Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein

Hem Moktan, Michel F. Guiraldelli, Craig A. Eyster, Weixing Zhao, Chih Ying Lee, Timothy Mather, R. Daniel Camerini-Otero, Patrick Sung, Donghua H. Zhou, Roberto J. Pezza

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: HOP2 protein promotes recombination and is required for meiotic chromosome synapsis. Results: The N terminus of HOP2 has a winged head DNA binding structure. Conclusion: The solution structure of the winged head DNA binding domain integrates biochemical and functional aspects of HOP2 recombinational function. Significance: Determining the three-dimensional structure of HOP2 is crucial to understand the mechanism of HOP2 action.

Original languageEnglish (US)
Pages (from-to)14682-14691
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number21
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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