Software for quantitative trait analysis

Laura Almasy, Diane M. Warren

    Research output: Contribution to journalReview article

    6 Scopus citations

    Abstract

    This paper provides a brief overview of software currently available for the genetic analysis of quantitative traits in humans. Programs that implement variance components, Markov Chain Monte Carlo (MCMC), Haseman-Elston (H-E) and penetrance model-based linkage analyses are discussed, as are programs for measured genotype association analyses and quantitative trait transmission disequilibrium tests. The software compared includes LINKAGE, FASTLINK, PAP, SOLAR, SEGPATH, ACT, Mx, MERLIN, GENEHUNTER, Loki, Mendel, SAGE, QTDT and FBAT. Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed.

    Original languageEnglish (US)
    Pages (from-to)191-195
    Number of pages5
    JournalHuman Genomics
    Volume2
    Issue number3
    DOIs
    Publication statusPublished - Sep 2005

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    Keywords

    • Association
    • Linkage analysis
    • QTL
    • Software

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Genetics
    • Drug Discovery

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