Software for quantitative trait analysis

Laura Almasy; Diane M. Warren

doi:10.1186/1479-7364-2-3-191

Software for quantitative trait analysis

Laura Almasy, Diane M. Warren

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

This paper provides a brief overview of software currently available for the genetic analysis of quantitative traits in humans. Programs that implement variance components, Markov Chain Monte Carlo (MCMC), Haseman-Elston (H-E) and penetrance model-based linkage analyses are discussed, as are programs for measured genotype association analyses and quantitative trait transmission disequilibrium tests. The software compared includes LINKAGE, FASTLINK, PAP, SOLAR, SEGPATH, ACT, Mx, MERLIN, GENEHUNTER, Loki, Mendel, SAGE, QTDT and FBAT. Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed.

Original language	English (US)
Pages (from-to)	191-195
Number of pages	5
Journal	Human Genomics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1186/1479-7364-2-3-191
State	Published - Sep 2005
Externally published	Yes

Keywords

Association
Linkage analysis
QTL
Software

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Drug Discovery

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10.1186/1479-7364-2-3-191

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AB - This paper provides a brief overview of software currently available for the genetic analysis of quantitative traits in humans. Programs that implement variance components, Markov Chain Monte Carlo (MCMC), Haseman-Elston (H-E) and penetrance model-based linkage analyses are discussed, as are programs for measured genotype association analyses and quantitative trait transmission disequilibrium tests. The software compared includes LINKAGE, FASTLINK, PAP, SOLAR, SEGPATH, ACT, Mx, MERLIN, GENEHUNTER, Loki, Mendel, SAGE, QTDT and FBAT. Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed.

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KW - Linkage analysis

KW - QTL

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Software for quantitative trait analysis

Abstract

Keywords

ASJC Scopus subject areas

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