Soft tissue volume augmentation by the use of collagen-based matrices: A volumetric analysis

Daniel S. Thoma, Ronald E. Jung, David Schneider, David L. Cochran, Andreas Ender, Archie A. Jones, Christoph Görlach, Lorenz Uebersax, Ursula Graf-Hausner, Christoph H.F. Hämmerle

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Objectives: The aim was to test whether or not soft tissue augmentation with a newly developed collagen matrix (CM) leads to volume gain in chronic ridge defects similar to those obtained by an autogenous subepithelial connective tissue graft (SCTG). Material and Methods: In six dogs, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to chronic ridge defects (CM, SCTG, sham-operated control). Impressions were taken before augmentation (baseline), at 28, and 84 days. The obtained casts were optically scanned and the images were digitally analysed. A defined region of interest was measured in all sites and the volume differences between the time points were calculated. Results: The mean volume differences per area between baseline and 28 days amounted to a gain of 1.6 mm (CM; SD±0.9), 1.5 mm (SCTG; ±0.1), and a loss of 0.003 mm (control; ±0.3). At 84 days, the mean volume differences per area to baseline measured a gain of 1.4 mm (CM; ±1.1), 1.4 mm (SCTG; ±0.4), and a loss of 0.3 mm (control; ±0.3). The differences between CM and SCTG were statistically significant compared with control at 28 and 84 days (p<0.001). Conclusion: Within the limits of this animal study, the CM may serve as a replacement for autogenous connective tissue.

Original languageEnglish (US)
Pages (from-to)659-666
Number of pages8
JournalJournal of Clinical Periodontology
Issue number7
StatePublished - Jul 2010


  • Collagen-based matrix
  • Soft tissue augmentation
  • Soft tissue volume
  • Subepithelial connective tissue graft
  • Volumetric measurement

ASJC Scopus subject areas

  • Periodontics


Dive into the research topics of 'Soft tissue volume augmentation by the use of collagen-based matrices: A volumetric analysis'. Together they form a unique fingerprint.

Cite this