Soft tissue volume augmentation by the use of collagen-based matrices in the dog mandible - A histological analysis

Daniel S. Thoma, Christoph H.F. Hämmerle, David L. Cochran, Archie A. Jones, Christoph Görlach, Lorenz Uebersax, Stephanie Mathes, Ursula Graf-Hausner, Ronald E. Jung

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Objectives The aim was to test, whether or not soft tissue volume augmentation with a specifically designed collagen matrix (CM), leads to ridge width gain in chronic ridge defects similar to those obtained by an autogenous subepithelial connective tissue graft (SCTG). Material and Methods In six dogs, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to chronic ridge defects [CM, SCTG and sham-operated control (Control)]. Dogs were sacrificed at 28 (n = 3) and 84 days (n = 3). Descriptive histology and histomorphometric measurements were performed on non-decalcified sections. Results SCTG and CM demonstrated favourable tissue integration, and subsequent re-modelling over 84 days. The overall mean amount of newly formed soft tissue (NMT) plus bone (NB) amounted to 3.8 ± 1.2 mm (Control), 6.4 ± 0.9 mm (CM) and 7.2 ± 1.2 mm (SCTG) at 28 days. At 84 days, the mean NMT plus NB reached 2.4 ± 0.9 mm (Control), 5.6 ± 1.5 mm (CM) and 6.0 ± 2.1 mm (SCTG). Statistically significant differences were observed between CM/SCTG and Control at both time-points (p < 0.05). Conclusion Within the limits of this animal model, the CM performed similar to the SCTG, based on histomorphometric outcomes combining NB and NMT.

Original languageEnglish (US)
Pages (from-to)1063-1070
Number of pages8
JournalJournal of Clinical Periodontology
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2011

Keywords

  • collagen-based matrix
  • soft tissue augmentation
  • soft tissue volume
  • subepithelial connective tissue graft

ASJC Scopus subject areas

  • Periodontics

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