Sodium-lithium countertransport activity is linked to chromosome 5 in baboons

Candace M. Kammerer, Laura A. Cox, Michael C. Mahaney, Jeffrey Rogers, Robert E. Shade

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The genes involved in the regulation of cellular sodium transport characteristics, which are correlated with some forms of essential hypertension, have not yet been identified. We are studying the genes and environmental factors that affect red blood cell sodium-lithium countertransport (SLC) activity and intracellular sodium (ICNa) concentration in 634 baboons that comprise 11 pedigrees of 2 and 3 generations each. To detect and locate possible quantitative trait loci (QTLs) that affect SLC activity and ICNa concentration, we performed a genome screen by using a maximum likelihood-based variance-components linkage analysis program (SOLAR). SLC and ICNa phenotypes as well as genotypes on 281 microsatellite loci were available for all pedigreed animals. Both SLC and ICNa traits were highly heritable (residual heritability 0.593±0.083 [P<0.0001] and 0.739±0.082 [P<0.0001]. respectively). We obtained evidence that a possible QTL for SLC activity is located on the baboon homologue of human chromosome 4 between D4S2456 and D4S2365 with a maximum multipoint lod score of 9.3 (P<10-10) near D4S1645. This QTL accounts for approximately two thirds of the total additive genetic variation in SLC activity in baboons. Although ICNa concentration was highly heritable, we found no evidence for linkage to a QTL with use of this methodology. Thus, we have evidence that a gene located on the baboon homologue of human chromosome 4 (baboon chromosome 5) affects cell sodium transport in baboons.

Original languageEnglish (US)
Pages (from-to)398-402
Number of pages5
JournalHypertension
Volume37
Issue number2 II
StatePublished - 2001
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 5
Papio
Lithium
Sodium
Quantitative Trait Loci
Chromosomes, Human, Pair 4
Human Chromosomes
Genes
Lod Score
Pedigree
Microsatellite Repeats
Erythrocytes
Genotype
Genome
Phenotype

Keywords

  • Blood pressure
  • Chromosome 5
  • Linkage
  • Sodium-lithium countertransport

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Kammerer, C. M., Cox, L. A., Mahaney, M. C., Rogers, J., & Shade, R. E. (2001). Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. Hypertension, 37(2 II), 398-402.

Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. / Kammerer, Candace M.; Cox, Laura A.; Mahaney, Michael C.; Rogers, Jeffrey; Shade, Robert E.

In: Hypertension, Vol. 37, No. 2 II, 2001, p. 398-402.

Research output: Contribution to journalArticle

Kammerer, CM, Cox, LA, Mahaney, MC, Rogers, J & Shade, RE 2001, 'Sodium-lithium countertransport activity is linked to chromosome 5 in baboons', Hypertension, vol. 37, no. 2 II, pp. 398-402.
Kammerer CM, Cox LA, Mahaney MC, Rogers J, Shade RE. Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. Hypertension. 2001;37(2 II):398-402.
Kammerer, Candace M. ; Cox, Laura A. ; Mahaney, Michael C. ; Rogers, Jeffrey ; Shade, Robert E. / Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. In: Hypertension. 2001 ; Vol. 37, No. 2 II. pp. 398-402.
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