Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology

Rodrigo B. Mansur, Graccielle R. Cunha, Elson Asevedo, André Zugman, Maiara Zeni-Graiff, Adiel C. Rios, Sumit Sethi, Pawan K. Maurya, Mateus L. Levandowski, Ary Gadelha, Pedro M. Pan, Laura Stertz, Síntia I. Belangero, Márcia Kauer San T. Anna, Antônio L. Teixeira, Jair J. Mari, Luis A. Rohde, Euripedes C. Miguel, Roger S. McIntyre, Rodrigo Grassi-OliveiraRodrigo A. Bressan, Elisa Brietzke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077). SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems.his work was supported by the following Brazilian government agencies: The National Council for Scientific and Technological Development (CNPq), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the São Paulo Research Foundation (FAPESP). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.>.

Original languageEnglish (US)
Article numbere0160455
JournalPloS one
Volume11
Issue number8
DOIs
StatePublished - Aug 2016
Externally publishedYes

ASJC Scopus subject areas

  • General

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