Small leucine-rich proteoglycans in the aging skeleton

Marian F. Young, Y. Bi, L. Ameye, T. Xu, S. Wadhwa, A. Heegaard, T. Kilts, X. D. Chen

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

Original languageEnglish (US)
Pages (from-to)364-365
Number of pages2
JournalJournal of Musculoskeletal Neuronal Interactions
Issue number4
StatePublished - Oct 2006
Externally publishedYes


  • Biglycan
  • Bone
  • Osteoblasts
  • Small Leucine Rich Proteoglycans (SLRPs)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine


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