Small leucine-rich proteoglycans in the aging skeleton

Marian F. Young; Y. Bi; L. Ameye; T. Xu; S. Wadhwa; A. Heegaard; T. Kilts; X. D. Chen

Small leucine-rich proteoglycans in the aging skeleton

Marian F. Young, Y. Bi, L. Ameye, T. Xu, S. Wadhwa, A. Heegaard, T. Kilts, X. D. Chen

Research output: Contribution to journal › Review article › peer-review

Abstract

Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

Original language	English (US)
Pages (from-to)	364-365
Number of pages	2
Journal	Journal of Musculoskeletal Neuronal Interactions
Volume	6
Issue number	4
State	Published - Oct 2006
Externally published	Yes

Keywords

Biglycan
Bone
Osteoblasts
Small Leucine Rich Proteoglycans (SLRPs)

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Orthopedics and Sports Medicine

Cite this

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abstract = "Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.",

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AU - Young, Marian F.

AU - Bi, Y.

AU - Ameye, L.

AU - Xu, T.

AU - Wadhwa, S.

AU - Heegaard, A.

AU - Kilts, T.

AU - Chen, X. D.

PY - 2006/10

Y1 - 2006/10

N2 - Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

AB - Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

KW - Biglycan

KW - Bone

KW - Osteoblasts

KW - Small Leucine Rich Proteoglycans (SLRPs)

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M3 - Review article

C2 - 17185826

AN - SCOPUS:33846259672

SN - 1108-7161

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JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

IS - 4

ER -

Small leucine-rich proteoglycans in the aging skeleton

Abstract

Keywords

ASJC Scopus subject areas

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