Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

doi:10.1016/j.drup.2011.08.003

Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

Original language	English (US)
Pages (from-to)	251-259
Number of pages	9
Journal	Drug Resistance Updates
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.drup.2011.08.003
State	Published - Dec 2011

Keywords

ACV
Acyclovir
Frameshift
Herpes simplex virus
Translational control

ASJC Scopus subject areas

Oncology
Pharmacology
Cancer Research
Infectious Diseases
Pharmacology (medical)

Access to Document

10.1016/j.drup.2011.08.003

Fingerprint Dive into the research topics of 'Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance'. Together they form a unique fingerprint.

Cite this

@article{8f7dee7e80d44063abfe2eacac5a8d56,

title = "Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance",

abstract = "Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.",

keywords = "ACV, Acyclovir, Frameshift, Herpes simplex virus, Translational control",

author = "Anthony Griffiths",

note = "Funding Information: I am grateful to Dr. Angela Pearson, Mallory Harden and Melanie Amen for helpful comments on the manuscript. I have received support from Texas Biomedical Research Institute V & I startup funds, grants from the Southwest Foundation Forum, Voelcker Foundation, and NCRR ( P51 RR013986 and R21 RR026287 ). Our research is conducted in facilities constructed with support from Research Facilities Improvement Program grant number C06 RR012087 from NCRR .",

year = "2011",

month = dec,

doi = "10.1016/j.drup.2011.08.003",

language = "English (US)",

volume = "14",

pages = "251--259",

journal = "Drug Resistance Updates",

issn = "1368-7646",

publisher = "Churchill Livingstone",

number = "6",

}

TY - JOUR

T1 - Slipping and sliding

T2 - Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

AU - Griffiths, Anthony

N1 - Funding Information: I am grateful to Dr. Angela Pearson, Mallory Harden and Melanie Amen for helpful comments on the manuscript. I have received support from Texas Biomedical Research Institute V & I startup funds, grants from the Southwest Foundation Forum, Voelcker Foundation, and NCRR ( P51 RR013986 and R21 RR026287 ). Our research is conducted in facilities constructed with support from Research Facilities Improvement Program grant number C06 RR012087 from NCRR .

PY - 2011/12

Y1 - 2011/12

N2 - Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

AB - Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

KW - ACV

KW - Acyclovir

KW - Frameshift

KW - Herpes simplex virus

KW - Translational control

UR - http://www.scopus.com/inward/record.url?scp=80054064328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054064328&partnerID=8YFLogxK

U2 - 10.1016/j.drup.2011.08.003

DO - 10.1016/j.drup.2011.08.003

M3 - Article

C2 - 21940196

AN - SCOPUS:80054064328

VL - 14

SP - 251

EP - 259

JO - Drug Resistance Updates

JF - Drug Resistance Updates

SN - 1368-7646

IS - 6

ER -

Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this