TY - JOUR
T1 - Slipping and sliding
T2 - Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance
AU - Griffiths, Anthony
N1 - Funding Information:
I am grateful to Dr. Angela Pearson, Mallory Harden and Melanie Amen for helpful comments on the manuscript. I have received support from Texas Biomedical Research Institute V & I startup funds, grants from the Southwest Foundation Forum, Voelcker Foundation, and NCRR ( P51 RR013986 and R21 RR026287 ). Our research is conducted in facilities constructed with support from Research Facilities Improvement Program grant number C06 RR012087 from NCRR .
PY - 2011/12
Y1 - 2011/12
N2 - Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.
AB - Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.
KW - ACV
KW - Acyclovir
KW - Frameshift
KW - Herpes simplex virus
KW - Translational control
UR - http://www.scopus.com/inward/record.url?scp=80054064328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054064328&partnerID=8YFLogxK
U2 - 10.1016/j.drup.2011.08.003
DO - 10.1016/j.drup.2011.08.003
M3 - Article
C2 - 21940196
AN - SCOPUS:80054064328
VL - 14
SP - 251
EP - 259
JO - Drug Resistance Updates
JF - Drug Resistance Updates
SN - 1368-7646
IS - 6
ER -