Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

doi:10.1016/j.drup.2011.08.003

Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

Original language	English (US)
Pages (from-to)	251-259
Number of pages	9
Journal	Drug Resistance Updates
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.drup.2011.08.003
State	Published - Dec 2011

Keywords

ACV
Acyclovir
Frameshift
Herpes simplex virus
Translational control

ASJC Scopus subject areas

Oncology
Pharmacology
Cancer Research
Infectious Diseases
Pharmacology (medical)

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10.1016/j.drup.2011.08.003

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