Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalDrug Resistance Updates
Volume14
Issue number6
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • ACV
  • Acyclovir
  • Frameshift
  • Herpes simplex virus
  • Translational control

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Cancer Research
  • Infectious Diseases
  • Pharmacology (medical)

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