Slipping and sliding: Frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance

Anthony Griffiths

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations

    Abstract

    Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

    Original languageEnglish (US)
    Pages (from-to)251-259
    Number of pages9
    JournalDrug Resistance Updates
    Volume14
    Issue number6
    DOIs
    StatePublished - Dec 2011

    Keywords

    • ACV
    • Acyclovir
    • Frameshift
    • Herpes simplex virus
    • Translational control

    ASJC Scopus subject areas

    • Oncology
    • Pharmacology
    • Cancer Research
    • Infectious Diseases
    • Pharmacology (medical)

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