Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Emerson M. Wickwire; Scott G. Williams; Thomas Roth; Vincent F. Capaldi; Michael Jaffe; Margaret Moline; Gholam K. Motamedi; Gregory W. Morgan; Vincent Mysliwiec; Anne Germain; Renee M. Pazdan; Reuven Ferziger; Thomas J. Balkin; Margaret E. MacDonald; Thomas A. Macek; Michael R. Yochelson; Steven M. Scharf; Christopher J. Lettieri

doi:10.1007/s13311-016-0429-3

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Emerson M. Wickwire, Scott G. Williams, Thomas Roth, Vincent F. Capaldi, Michael Jaffe, Margaret Moline, Gholam K. Motamedi, Gregory W. Morgan, Vincent Mysliwiec, Anne Germain, Renee M. Pazdan, Reuven Ferziger, Thomas J. Balkin, Margaret E. MacDonald, Thomas A. Macek, Michael R. Yochelson, Steven M. Scharf, Christopher J. Lettieri

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

Original language	English (US)
Pages (from-to)	403-417
Number of pages	15
Journal	Neurotherapeutics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s13311-016-0429-3
State	Published - Apr 1 2016
Externally published	Yes

Keywords

Concussion
Insomnia
Sleep
Sleep apnea
Sleep disorders
Traumatic brain injury

ASJC Scopus subject areas

Pharmacology
Clinical Neurology
Pharmacology (medical)

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10.1007/s13311-016-0429-3

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Wickwire, E. M., Williams, S. G., Roth, T., Capaldi, V. F., Jaffe, M., Moline, M., Motamedi, G. K., Morgan, G. W., Mysliwiec, V., Germain, A., Pazdan, R. M., Ferziger, R., Balkin, T. J., MacDonald, M. E., Macek, T. A., Yochelson, M. R., Scharf, S. M., & Lettieri, C. J. (2016). Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group. Neurotherapeutics, 13(2), 403-417. https://doi.org/10.1007/s13311-016-0429-3

Wickwire, EM, Williams, SG, Roth, T, Capaldi, VF, Jaffe, M, Moline, M, Motamedi, GK, Morgan, GW, Mysliwiec, V, Germain, A, Pazdan, RM, Ferziger, R, Balkin, TJ, MacDonald, ME, Macek, TA, Yochelson, MR, Scharf, SM & Lettieri, CJ 2016, 'Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group', Neurotherapeutics, vol. 13, no. 2, pp. 403-417. https://doi.org/10.1007/s13311-016-0429-3

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abstract = "Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.",

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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Abstract

Keywords

ASJC Scopus subject areas

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