@article{38814ff9dead44d9a78db51d4d09098a,
title = "skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo",
abstract = "By the 4-cell stage of C. elegans embryogenesis, a ventral blastomere, called EMS, is already committed to producing pharyngeal and intestinal cell types. Recessive, maternal-effect mutations in the gene skn-1 prevent EMS from producing both pharyngeal and intestinal cells. In skn-1 mutant embryos, EMS instead produces hypodermal cells and body wall muscle cells, much like its sister blastomere. Genetic analysis suggests that the skn-1 gene product is also required required post-embryonically for development of the intestine. We have cloned and sequenced the skn-1 gene and describe sequence similarities to the basic regions of bZIP transcription factors. We propose that the maternally expressed skn-1 gene product acts to specify the fate of the EMS blastomere.",
author = "Bruce Bowerman and Eaton, {Benjamin A.} and Priess, {James R.}",
note = "Funding Information: The authors thank Tabitha Doniach, David Miller, Nipam Patel, and Susan Strome for providing antibodies; Saechim Kim and Robert Hor-viitz for the deficiency nDf41; John Sulston and Alan Coulson for provid-lng cosmid clones of C. elegans genomic DNA, which enabled us to map and clone skn-7; Joel Rothman for communicating unpublished information; Stuart Kim, Bob Barstead, and Bob Waterston for cDNA libraries; Susan Strome for the strain SS104(bn2); the C. elegans Ge-nettcs Center for many strains; Chris Field for pointing out the similarity of skn-7 to mastermind and zeste; Jim Wallace and Steve Henikoff for assistance in computer searches; Mike Krause for molecular advice; Craig Mello for instructions on C. elegans transformation and comments on the manuscript; Bruce Draper for adviceon photography and his daily advances in lab techniques; Craig Mello, Mike Krause, and Bruce Draper for finding three skn-7 alleles; Hal Weintraub for helpful diiscussions; and Dominique Heffel and Nicolas Eisen for technical assistance. J. R. P. was supported by grants from the NIH and the American Cancer Society, and B. 8. was supported by a fellowship from the Jane Coffin Childs Medical Research Fund.",
year = "1992",
month = mar,
day = "20",
doi = "10.1016/0092-8674(92)90078-Q",
language = "English (US)",
volume = "68",
pages = "1061--1075",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "6",
}