Skin Tumor-Initiating Activities of The Twelve Isomeric Phenols of Benzo(A)Pyrene

T. J. Slaga, W. M. Bracken, S. Dresner, W. Levin, H. Yagi, D. M. Jerina, A. H. Conney

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The skin tumor-initiating activities of the 12 isomeric phenols of benzo(a)pyrene (BP) were determined in mice by use of a two-stage system of tumorigenesis. 11-Hydroxybenzo(a)pyrene was moderately active, whereas 2-hydroxybenzo(a)pyrene and BP were strong tumor initiators when applied topically to CD-1 mice and followed by twice-weekly applications of the promoter 12-0-tetradeca noylph or bol-13-acetate. 1-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, and 12-hydroxybenzo(a)pyrene had less than 5% of the tumor-initiating activity of BP when the data were expressed as papillomas per mouse. After 30 weeks of promotion, the number of papillomas per mouse was 8.4, 8.5, and 2.8, respectively, for the animals treated with BP, 2-hydroxybenzo(a)pyrene, and 11-hydroxybenzo(a)pyrene. A 5-week latency period before the appearance of the first tumor was observed after the application of either 2-hydroxybenzo(a)pyrene or BP, whereas a slightly longer latency period of 7 weeks was observed following application of 11-hydroxybenzo(a)pyrene. The time required for 50% of the animals to develop tumors was 13 weeks for animals treated with BP and 15 weeks for animals treated with 2- or 11-hydroxybenzo(a)pyrene.

Original languageEnglish (US)
Pages (from-to)678-681
Number of pages4
JournalCancer Research
Issue number3
StatePublished - Mar 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Skin Tumor-Initiating Activities of The Twelve Isomeric Phenols of Benzo(A)Pyrene'. Together they form a unique fingerprint.

Cite this