Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

Thomas J. Slaga, Aurora Viaje, David L. Berry, William Bracken, Steven G. Buty, John D. Scribner

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Abstract

The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalCancer Letters
Volume2
Issue number2
DOIs
StatePublished - Nov 1976

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Slaga, T. J., Viaje, A., Berry, D. L., Bracken, W., Buty, S. G., & Scribner, J. D. (1976). Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol. Cancer Letters, 2(2), 115-121. https://doi.org/10.1016/S0304-3835(76)80020-1