Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

Thomas J. Slaga; Aurora Viaje; David L. Berry; William Bracken; Steven G. Buty; John D. Scribner

doi:10.1016/S0304-3835(76)80020-1

Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

Thomas J. Slaga, Aurora Viaje, David L. Berry, William Bracken, Steven G. Buty, John D. Scribner

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

Original language	English (US)
Pages (from-to)	115-121
Number of pages	7
Journal	Cancer Letters
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(76)80020-1
State	Published - Nov 1976
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol",

abstract = "The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.",

author = "Slaga, {Thomas J.} and Aurora Viaje and Berry, {David L.} and William Bracken and Buty, {Steven G.} and Scribner, {John D.}",

year = "1976",

month = nov,

doi = "10.1016/S0304-3835(76)80020-1",

language = "English (US)",

volume = "2",

pages = "115--121",

journal = "Cancer Letters",

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T1 - Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

AU - Slaga, Thomas J.

AU - Viaje, Aurora

AU - Berry, David L.

AU - Bracken, William

AU - Buty, Steven G.

AU - Scribner, John D.

PY - 1976/11

Y1 - 1976/11

N2 - The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

AB - The skin tumor initiating abilities of both K-region and non-K-region epoxides of benzo(a)pyrene(BP) were determined in mice using a two-stage system of tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was found to be approximately as potent as BP suggesting that it may be a proximate carcinogen.

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Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

Abstract

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