Skeletal muscle spasm and a review of muscle relaxants

J. C. De Lee, Charles A Rockwood Jr

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Muscle spasm of local origin, while not life-threatening, can be extremely painful and disabling. Therapeutic intervention is advisable to help the patient return to normal activity as soon as possible. Since the discovery of mephenesin in 1946 clinicians have had available an increasing variety of skeletal muscle relaxants. A review of the recently published literature reveals that most of the drugs demonstrated superiority over placebo in controlled studies, but that many relied upon the undesirable side effect of sedation for their muscle relaxing properties. Cyclobenzaprine has been demonstrated to be repeatedly more effective than placebo and in several studies to be more effective than diazepam in treating muscle spasms of local origin. Data suggest that while drowsiness is the most common side effect of cyclobenzaprine administration, the effectiveness of the drug is independent of any sedative effect. The considerable recent literature supporting the safety and efficacy of cyclobenzaprine for acute muscle spasm of local origin indicates that this most recently introduced agent may represent a valuable addition to the available treatment modalities.

Original languageEnglish (US)
Pages (from-to)64-74
Number of pages11
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume27
Issue number1
StatePublished - 1980

Fingerprint

Spasm
Skeletal Muscle
Muscles
Mephenesin
Placebos
Neuromuscular Agents
Sleep Stages
Diazepam
Hypnotics and Sedatives
Pharmaceutical Preparations
Safety
Therapeutics
cyclobenzaprine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Skeletal muscle spasm and a review of muscle relaxants. / De Lee, J. C.; Rockwood Jr, Charles A.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 27, No. 1, 1980, p. 64-74.

Research output: Contribution to journalArticle

De Lee, J. C. ; Rockwood Jr, Charles A. / Skeletal muscle spasm and a review of muscle relaxants. In: Current Therapeutic Research - Clinical and Experimental. 1980 ; Vol. 27, No. 1. pp. 64-74.
@article{683cce5fcedc41eb9cf16346687684ca,
title = "Skeletal muscle spasm and a review of muscle relaxants",
abstract = "Muscle spasm of local origin, while not life-threatening, can be extremely painful and disabling. Therapeutic intervention is advisable to help the patient return to normal activity as soon as possible. Since the discovery of mephenesin in 1946 clinicians have had available an increasing variety of skeletal muscle relaxants. A review of the recently published literature reveals that most of the drugs demonstrated superiority over placebo in controlled studies, but that many relied upon the undesirable side effect of sedation for their muscle relaxing properties. Cyclobenzaprine has been demonstrated to be repeatedly more effective than placebo and in several studies to be more effective than diazepam in treating muscle spasms of local origin. Data suggest that while drowsiness is the most common side effect of cyclobenzaprine administration, the effectiveness of the drug is independent of any sedative effect. The considerable recent literature supporting the safety and efficacy of cyclobenzaprine for acute muscle spasm of local origin indicates that this most recently introduced agent may represent a valuable addition to the available treatment modalities.",
author = "{De Lee}, {J. C.} and {Rockwood Jr}, {Charles A}",
year = "1980",
language = "English (US)",
volume = "27",
pages = "64--74",
journal = "Current Therapeutic Research",
issn = "0011-393X",
publisher = "Excerpta Medica",
number = "1",

}

TY - JOUR

T1 - Skeletal muscle spasm and a review of muscle relaxants

AU - De Lee, J. C.

AU - Rockwood Jr, Charles A

PY - 1980

Y1 - 1980

N2 - Muscle spasm of local origin, while not life-threatening, can be extremely painful and disabling. Therapeutic intervention is advisable to help the patient return to normal activity as soon as possible. Since the discovery of mephenesin in 1946 clinicians have had available an increasing variety of skeletal muscle relaxants. A review of the recently published literature reveals that most of the drugs demonstrated superiority over placebo in controlled studies, but that many relied upon the undesirable side effect of sedation for their muscle relaxing properties. Cyclobenzaprine has been demonstrated to be repeatedly more effective than placebo and in several studies to be more effective than diazepam in treating muscle spasms of local origin. Data suggest that while drowsiness is the most common side effect of cyclobenzaprine administration, the effectiveness of the drug is independent of any sedative effect. The considerable recent literature supporting the safety and efficacy of cyclobenzaprine for acute muscle spasm of local origin indicates that this most recently introduced agent may represent a valuable addition to the available treatment modalities.

AB - Muscle spasm of local origin, while not life-threatening, can be extremely painful and disabling. Therapeutic intervention is advisable to help the patient return to normal activity as soon as possible. Since the discovery of mephenesin in 1946 clinicians have had available an increasing variety of skeletal muscle relaxants. A review of the recently published literature reveals that most of the drugs demonstrated superiority over placebo in controlled studies, but that many relied upon the undesirable side effect of sedation for their muscle relaxing properties. Cyclobenzaprine has been demonstrated to be repeatedly more effective than placebo and in several studies to be more effective than diazepam in treating muscle spasms of local origin. Data suggest that while drowsiness is the most common side effect of cyclobenzaprine administration, the effectiveness of the drug is independent of any sedative effect. The considerable recent literature supporting the safety and efficacy of cyclobenzaprine for acute muscle spasm of local origin indicates that this most recently introduced agent may represent a valuable addition to the available treatment modalities.

UR - http://www.scopus.com/inward/record.url?scp=0018918752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018918752&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0018918752

VL - 27

SP - 64

EP - 74

JO - Current Therapeutic Research

JF - Current Therapeutic Research

SN - 0011-393X

IS - 1

ER -