Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists

M. M.A.L. Pelsers, K. Tsintzas, H. Boon, K. Jewell, L. Norton, J. J.F.P. Luiken, J. F.C. Glatz, L. J.C. Van Loon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Aim: Membrane fatty acid transporters can modulate the balance between fatty acid uptake and subsequent storage and/or oxidation in muscle tissue. As such, skeletal muscle fatty acid transporter protein expression could play an important role in the etiology of insulin resistance and/or type 2 diabetes. Methods: In the present study, fatty acid translocase (FAT/CD36), plasma membrane-bound fatty acid-binding protein (FABPpm) and fatty acid transport protein 1 (FATP1) mRNA and protein expression were assessed in muscle tissue obtained from 10 sedentary, overweight type 2 diabetes patients (60 ± 2 years), 10 sedentary, weight-matched normoglycemic controls (60 ± 2 years) and 10 age-matched, endurance trained cyclists (57 ± 1 years). Results: Both FAT/CD36 and FATP1 mRNA and protein expression did not differ between groups. In contrast, FABPpm mRNA and protein expression were approx. 30-40% higher in the trained men compared with the diabetes patients (P < 0.01) and sedentary controls (P < 0.05). Conclusions: Skeletal muscle FAT/CD36, FABPpm and FATP1 mRNA and protein expression are not up- or downregulated in a sedentary and/or insulin resistant state. In contrast, FABPpm expression is upregulated in the endurance trained state and likely instrumental to allow greater fatty acid oxidation rates.

Original languageEnglish (US)
Pages (from-to)209-219
Number of pages11
JournalActa Physiologica
Volume190
Issue number3
DOIs
StatePublished - Jul 2007
Externally publishedYes

Keywords

  • CD36
  • Exercise
  • FABPpm
  • FATP1
  • GLUT4
  • Metabolism
  • Muscle

ASJC Scopus subject areas

  • Physiology

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    Pelsers, M. M. A. L., Tsintzas, K., Boon, H., Jewell, K., Norton, L., Luiken, J. J. F. P., Glatz, J. F. C., & Van Loon, L. J. C. (2007). Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists. Acta Physiologica, 190(3), 209-219. https://doi.org/10.1111/j.1748-1716.2007.01698.x