Site of splenic autotransplantation affects protection from sepsis

Charles D. Livingston, Barry A. Levine, Kenneth R. Sirinek

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Using an animal model with bacteria delivered through the respiratory tract, the relative protective effects of subcutaneous and intraperitoneal splenic autotransplants were compared. Animals with intraperitoneal implants demonstrated a mortality not different from that in control animals and an early mortality significantly lower than found in splenectomized animals. Subcutaneous splenic autotransplantation provided no protective effect. The inability of extraperitoneal subcutaneous implants to protect against postsplenectomy pulmonary sepsis in our model suggests that subcutaneous splenic autotransplantation is an inappropriate alternative to intraperitoneal splenic autotransplantation in the clinical setting.

Original languageEnglish (US)
Pages (from-to)734-737
Number of pages4
JournalThe American Journal of Surgery
Volume146
Issue number6
DOIs
StatePublished - Dec 1983

ASJC Scopus subject areas

  • Surgery

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