Abstract
Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 801-803 |
| Number of pages | 3 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 33 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2022 |
Keywords
- SIRT6
- deacetylation
- fatty acid oxidation
- lipid metabolism
- long-chain acyl-CoA synthase 5
- nonalcoholic fatty liver disease
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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