SIRT6: therapeutic target for nonalcoholic fatty liver disease

Mengwei Zang, Bin Gao

Research output: Contribution to journalShort surveypeer-review

Abstract

Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).

Original languageEnglish (US)
Pages (from-to)801-803
Number of pages3
JournalTrends in Endocrinology and Metabolism
Volume33
Issue number12
DOIs
StatePublished - Dec 2022

Keywords

  • deacetylation
  • fatty acid oxidation
  • lipid metabolism
  • long-chain acyl-CoA synthase 5
  • nonalcoholic fatty liver disease
  • SIRT6

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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