Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).
- fatty acid oxidation
- lipid metabolism
- long-chain acyl-CoA synthase 5
- nonalcoholic fatty liver disease
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism