TY - JOUR
T1 - Sirolimus plus sorafenib in treating HCC recurrence after liver transplantation
T2 - A case report
AU - Wang, Yubao
AU - Speeg, Kermit V.
AU - Washburn, William Kenneth
AU - Halff, Glenn
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2010/11/21
Y1 - 2010/11/21
N2 - A case of hepatocellular carcinoma (HCC) with pulmonary recurrence after liver transplantation for HCC is presented in this report. The patient showed disease progression on sorafenib therapy demonstrated by computed tomography scans as well as serial serum α-fetoprotein (AFP) elevation. After his immunosuppression therapy was successfully transitioned to sirolimus and a continuation of sorafenib, he achieved partial remission based on RECIST criteria and normalization of AFP. Mammalian target of rapamycin inhibitors including sirolimus alone or in conjunction with sorafenib may be useful in the treatment of post transplant HCC.
AB - A case of hepatocellular carcinoma (HCC) with pulmonary recurrence after liver transplantation for HCC is presented in this report. The patient showed disease progression on sorafenib therapy demonstrated by computed tomography scans as well as serial serum α-fetoprotein (AFP) elevation. After his immunosuppression therapy was successfully transitioned to sirolimus and a continuation of sorafenib, he achieved partial remission based on RECIST criteria and normalization of AFP. Mammalian target of rapamycin inhibitors including sirolimus alone or in conjunction with sorafenib may be useful in the treatment of post transplant HCC.
KW - Hepatocellular carcinoma
KW - Liver transplantation
KW - Mammalian target of rapamycin inhibitor
KW - Sirolimus
KW - Sorafenib
UR - http://www.scopus.com/inward/record.url?scp=78649687544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649687544&partnerID=8YFLogxK
U2 - 10.3748/wjg.v16.i43.5518
DO - 10.3748/wjg.v16.i43.5518
M3 - Article
C2 - 21086573
AN - SCOPUS:78649687544
SN - 1007-9327
VL - 16
SP - 5518
EP - 5522
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 43
ER -