Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: An immunohistologic, ultrastructural, and cytogenetic study

Daisy Saw, John K C Chan, Jaishree Jagirdar, M. Alba Greco, Michael Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas.

Original languageEnglish (US)
Pages (from-to)896-899
Number of pages4
JournalHuman Pathology
Volume23
Issue number8
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Retinoblastoma
Cytogenetics
Radiotherapy
Neoplasms
Peripheral Primitive Neuroectodermal Tumors
Primitive Neuroectodermal Tumors
Chromosomes, Human, Pair 13
Synaptophysin
S100 Proteins
Phosphopyruvate Hydratase
Glycogen
Chromosome Aberrations

Keywords

  • immunohistochemistry
  • radiation
  • retinoblastoma
  • sinonasal neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma : An immunohistologic, ultrastructural, and cytogenetic study. / Saw, Daisy; Chan, John K C; Jagirdar, Jaishree; Greco, M. Alba; Lee, Michael.

In: Human Pathology, Vol. 23, No. 8, 1992, p. 896-899.

Research output: Contribution to journalArticle

Saw, Daisy ; Chan, John K C ; Jagirdar, Jaishree ; Greco, M. Alba ; Lee, Michael. / Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma : An immunohistologic, ultrastructural, and cytogenetic study. In: Human Pathology. 1992 ; Vol. 23, No. 8. pp. 896-899.
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