Abstract
Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 896-899 |
| Number of pages | 4 |
| Journal | Human Pathology |
| Volume | 23 |
| Issue number | 8 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- immunohistochemistry
- radiation
- retinoblastoma
- sinonasal neoplasm
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma : An immunohistologic, ultrastructural, and cytogenetic study. / Saw, Daisy; Chan, John K C; Jagirdar, Jaishree; Greco, M. Alba; Lee, Michael.
In: Human Pathology, Vol. 23, No. 8, 1992, p. 896-899.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma
T2 - An immunohistologic, ultrastructural, and cytogenetic study
AU - Saw, Daisy
AU - Chan, John K C
AU - Jagirdar, Jaishree
AU - Greco, M. Alba
AU - Lee, Michael
PY - 1992
Y1 - 1992
N2 - Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas.
AB - Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas.
KW - immunohistochemistry
KW - radiation
KW - retinoblastoma
KW - sinonasal neoplasm
UR - http://www.scopus.com/inward/record.url?scp=0026688568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026688568&partnerID=8YFLogxK
U2 - 10.1016/0046-8177(92)90401-N
DO - 10.1016/0046-8177(92)90401-N
M3 - Article
C2 - 1322860
AN - SCOPUS:0026688568
VL - 23
SP - 896
EP - 899
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 8
ER -