Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression

F. C. Redmond, C. L. Bowden, L. S. Lehmann, B. C. Stanton

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Issue number4
StatePublished - 1980

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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