Abstract
Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 635-642 |
| Number of pages | 8 |
| Journal | Current Therapeutic Research - Clinical and Experimental |
| Volume | 27 |
| Issue number | 4 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Medicine(all)
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Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression. / Redmond, Franklin C; Bowden, C. L.; Lehmann, L. S.; Stanton, B. C.
In: Current Therapeutic Research - Clinical and Experimental, Vol. 27, No. 4, 1980, p. 635-642.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression
AU - Redmond, Franklin C
AU - Bowden, C. L.
AU - Lehmann, L. S.
AU - Stanton, B. C.
PY - 1980
Y1 - 1980
N2 - Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.
AB - Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018821998&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0018821998
VL - 27
SP - 635
EP - 642
JO - Current Therapeutic Research
JF - Current Therapeutic Research
SN - 0011-393X
IS - 4
ER -