Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.
|Original language||English (US)|
|Number of pages||8|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|State||Published - Jan 1 1980|
ASJC Scopus subject areas
- Pharmacology (medical)