Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression

Franklin C Redmond, C. L. Bowden, L. S. Lehmann, B. C. Stanton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Eleven adult patients received a single 100-mg dose of amitriptyline or nortriptyline for pharmacokinetic assessment prior to being placed on a regular dosage of the same drug to achieve steady-state concentrations. Drug plasma levels were determined by a gas chromatographic electron capture detector procedure. For both amitriptyline and nortriptyline there was a high correlation between the plasma concentration measured 18 to 42 hours after the single dose and the steady-state concentration. One half of the steady state variability was accounted for by the single-dose drug level determination. A simple formula was devised using the blood level obtained after a test dose to predict the dosage necessary to obtain a desired steady-state concentration. The data suggest that this approach may have practical clinical value in initiating treatment with tricyclic antidepressants.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume27
Issue number4
StatePublished - 1980

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Nortriptyline
Amitriptyline
Depressive Disorder
Pharmaceutical Preparations
Tricyclic Antidepressive Agents
Pharmacokinetics
Gases
Electrons
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression. / Redmond, Franklin C; Bowden, C. L.; Lehmann, L. S.; Stanton, B. C.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 27, No. 4, 1980, p. 635-642.

Research output: Contribution to journalArticle

Redmond, Franklin C ; Bowden, C. L. ; Lehmann, L. S. ; Stanton, B. C. / Single-dose prediction of amitriptyline and nortriptyline requirement in unipolar depression. In: Current Therapeutic Research - Clinical and Experimental. 1980 ; Vol. 27, No. 4. pp. 635-642.
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