Sinais neurológicos sutis: Uma revisão

Translated title of the contribution: Neurological soft signs: A review

Vinicius Sousa Pietra Pedroso, João Vinícius Salgado, Antônio Lúcio Teixeira

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


This work aims to discuss the meaning of neurological soft signs and their relevance for research in psychiatry, with emphasis in schizophrenia and bipolar disorder. A narrative review of the literature was performed based on the databases Medline and Bireme. Neurological soft signs are abnormalities on the neurological exam affecting several functions, such as sensory integration, motor coordination, motor sequencing and presence of primitive reflexes. These signs indicate non-focal brain dysfunction and can be regarded as risk factors for psychiatric disorders. They can also suggest endophenotypes related with specific neural circuits, providing relevant information on the pathofisiology of these disorders. There are only a few studies on this subject in the Brazilian literature. The observation of neurological soft signs points to the potential of the neurological exam to link the neurobiological knowledge and the clinical practice.

Translated title of the contributionNeurological soft signs: A review
Original languagePortuguese
Pages (from-to)233-237
Number of pages5
JournalJornal Brasileiro de Psiquiatria
Issue number3
StatePublished - 2010
Externally publishedYes


  • Bipolar disorder
  • Neurological soft signs
  • Psychiatry
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


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