Sin3b Interacts with Myc and decreases Myc levels

Pablo Garcia-Sanz, Andrea Quintanilla, M. Carmen Lafita, Gema Moreno-Bueno, Lucia García-Gutierrez, Vedrana Tabor, Ignacio Varela, Yuzuru Shiio, Lars Gunnar Larsson, Francisco Portillo, Javier Leon

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Myc is an oncogenic transcription factor that is frequently deregulated in cancer, and Sin3b is a transcriptional regulator that recruits histone deacetylases. Results: A new interaction between the protein Sin3b and Myc that leads to Myc down-regulation is described. Conclusion: Sin3b-Myc interaction regulates Myc levels and activity. Significance: Sin3b adds a second level of control of Myc by directly regulating Myc levels.

Original languageEnglish (US)
Pages (from-to)22221-22236
Number of pages16
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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