Sin3b Interacts with Myc and decreases Myc levels

Pablo Garcia-Sanz, Andrea Quintanilla, M. Carmen Lafita, Gema Moreno-Bueno, Lucia García-Gutierrez, Vedrana Tabor, Ignacio Varela, Yuzuru Shiio, Lars Gunnar Larsson, Francisco Portillo, Javier Leon

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16 Scopus citations

Abstract

Background: Myc is an oncogenic transcription factor that is frequently deregulated in cancer, and Sin3b is a transcriptional regulator that recruits histone deacetylases. Results: A new interaction between the protein Sin3b and Myc that leads to Myc down-regulation is described. Conclusion: Sin3b-Myc interaction regulates Myc levels and activity. Significance: Sin3b adds a second level of control of Myc by directly regulating Myc levels.

Original languageEnglish (US)
Pages (from-to)22221-22236
Number of pages16
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
Publication statusPublished - Aug 8 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Garcia-Sanz, P., Quintanilla, A., Lafita, M. C., Moreno-Bueno, G., García-Gutierrez, L., Tabor, V., ... Leon, J. (2014). Sin3b Interacts with Myc and decreases Myc levels. Journal of Biological Chemistry, 289(32), 22221-22236. https://doi.org/10.1074/jbc.M113.538744