Simultaneous appearance of keratin modifications and γ-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas

A. J. Klein-Szanto, K. G. Nelson, Y. Shah, T. J. Slaga

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

γ-Glutamyltransferase (GGT), an enzyme not found in normal adult epidermis, was detected in most skin papillomas larger than 13 mm in diameter and in all squamous carcinomas induced by 7,12-dimethylbenz[a]anthracene initiation and 12-O-tetradecanoyl-phorbol 13-acetate promotion in noninbred Sencar mice. Furthermore, these GGT-positive lesions were also characterized by a marked decrease or absence of high-molecular-weight components of epidermal keratin. Since these characteristics are common to both carcinomas and large papillomas but are practically undetectable in normal epidermis and small papillomas, GGT activity and lack of high-molecular-weight keratin components seem to be good indicators of tumor progression, i.e., from papilloma to squamous carcinoma.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalJournal of the National Cancer Institute
Volume70
Issue number1
StatePublished - Apr 7 1983
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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