Simulation of a common oligogenic disease with quantitative risk factors. GAW9 problem 2: The answers

Jean W. MacCluer, John Blangero, Thomas D. Dyer, Candace M. Kammerer

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    For Problem 2, simulated family data were provided for a common oligogenic disease that was defined by imposing a threshold, T, on a quantitative trait, Q1. Every individual with a value of Q1 > T (where T = 87.5) was defined as affected. Participants were told that three other quantitative traits (Q2, Q3, and Q4) and an environmental factor (EF) also were thought to be associated with the disease as intervening variables, and that 12 candidate loci (C1 ‐ C12) were postulated to influence traits associated with the disease. The tasks for GAW9 were to characterize the genetic and environmental contribution to Q1 (and the disease), Q2, Q3, and Q4, and to localize any single genes that had detectable effects. © 1995 Wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)707-712
    Number of pages6
    JournalGenetic epidemiology
    Volume12
    Issue number6
    DOIs
    StatePublished - 1995

    Keywords

    • oligogenic traits
    • quantitative traits

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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