Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs

Erik De Schutter, James M. Bower

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Cerebellar Purkinje cell responses to granule cell synaptic inputs were examined with a computer model including active dendritic conductances. Dendritic P-type Ca2+ channels amplified postsynaptic responses when the model was firing at a physiological rate. Small synchronous excitatory inputs applied distally on the large dendritic tree resulted in somatic responses of similar size to those generated by more proximal inputs. In contrast, in a passive model the somatic postsynaptic potentials to distal inputs were 76% smaller. The model predicts that the somatic firing response of Purkinje cells is relatively insensitive to the exact dendritic location of synaptic inputs. We describe a mechanism of Ca2+-mediated synaptic amplification, based on the subspiking threshold recruitment of P-type Ca2+ channels in the dendritic branches surrounding the input site.

Original languageEnglish (US)
Pages (from-to)4736-4740
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number11
DOIs
StatePublished - May 24 1994

Keywords

  • amplification
  • calcium channel
  • cerebellum
  • model
  • parallel fiber

ASJC Scopus subject areas

  • General

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