Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

Seymore Herling, Edward H. Coale, David W. Hein, Gail Winger, James H. Woods

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds that are generally considered to belong to distinct pharmacological classes.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalPsychopharmacology
Volume73
Issue number3
DOIs
StatePublished - May 1981

Keywords

  • Cyclazocine
  • Dextrorphan
  • Drug discrimination
  • Ethylketazocine
  • Ketamine
  • Nalorphine
  • Phencyclidine
  • Pigeons

ASJC Scopus subject areas

  • Pharmacology

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