Simian immunodeficiency virus needlestick accident in a laboratory worker

R. F. Khabbaz; T. Rowe; W. M. Heneine; J. E. Kaplan; T. M. Folks; C. A. Schable; J. R. George; C. Pau; B. S. Parekh; J. W. Curran; G. Schochetman; M. D. Lairmore; M. Murphey-Corb

doi:10.1016/0140-6736(92)92358-M

Simian immunodeficiency virus needlestick accident in a laboratory worker

R. F. Khabbaz, T. Rowe, W. M. Heneine, J. E. Kaplan, T. M. Folks, C. A. Schable, J. R. George, C. Pau, B. S. Parekh, J. W. Curran, G. Schochetman, M. D. Lairmore, M. Murphey-Corb

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Abstract

The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.

Original language	English (US)
Pages (from-to)	271-273
Number of pages	3
Journal	The Lancet
Volume	340
Issue number	8814
DOIs	https://doi.org/10.1016/0140-6736(92)92358-M
State	Published - Aug 1 1992

ASJC Scopus subject areas

Medicine(all)

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title = "Simian immunodeficiency virus needlestick accident in a laboratory worker",

abstract = "The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.",

author = "Khabbaz, {R. F.} and T. Rowe and Heneine, {W. M.} and Kaplan, {J. E.} and Folks, {T. M.} and Schable, {C. A.} and George, {J. R.} and C. Pau and Parekh, {B. S.} and Curran, {J. W.} and G. Schochetman and Lairmore, {M. D.} and M. Murphey-Corb",

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AU - Khabbaz, R. F.

AU - Rowe, T.

AU - Heneine, W. M.

AU - Kaplan, J. E.

AU - Folks, T. M.

AU - Schable, C. A.

AU - George, J. R.

AU - Pau, C.

AU - Parekh, B. S.

AU - Curran, J. W.

AU - Schochetman, G.

AU - Lairmore, M. D.

AU - Murphey-Corb, M.

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AB - The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.

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Simian immunodeficiency virus needlestick accident in a laboratory worker

Abstract

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