Simian immunodeficiency virus needlestick accident in a laboratory worker

R. F. Khabbaz, T. Rowe, W. M. Heneine, J. E. Kaplan, T. M. Folks, C. A. Schable, J. R. George, C. Pau, B. S. Parekh, J. W. Curran, G. Schochetman, M. D. Lairmore, M. Murphey-Corb

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations


    The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.

    Original languageEnglish (US)
    Pages (from-to)271-273
    Number of pages3
    JournalThe Lancet
    Issue number8814
    StatePublished - Aug 1 1992

    ASJC Scopus subject areas

    • Medicine(all)


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