Simian foamy virus infection in a blood donor.

R. S. Boneva, A. J. Grindon, S. L. Orton, W. M. Switzer, Vedapuri Shanmugam, A. I. Hussain, V. B. Bhullar, M. E. Chamberland, Walid Heneine, T. M. Folks, L. E. Chapman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

BACKGROUND: Infections with simian foamy virus (SFV) are widely prevalent in nonhuman primates. SFV infection was confirmed in a worker, occupationally exposed to nonhuman primates, who donated blood after the retrospectively documented date of infection. Human-to-human transmission of SFV through transfusion and its pathogenicity have not been studied. STUDY DESIGN AND METHODS: Recipients of blood from this donor were identified and blood samples from such recipients were tested for SFV infection by Western blot and PCR assay. RESULTS: One recipient of RBCs and another recipient of FFP had died; retroviral infections were not implicated. One platelet recipient could not be tested. Recipients of RBCs (two), a WBC-reduced RBC unit (one), and a platelet unit (one) tested SFV-negative 19 months to 7 years after transfusion. Tested recipients had transfusions 3 to 35 days after blood donation. Samples of one lot of albumin and three lots of plasma protein fraction (manufactured from recovered plasma from two donations) tested negative both for antibodies and for viral RNA. CONCLUSION: SFV transmission through transfusion was not identified among four recipients of cellular blood components from one SFV-infected donor. Derivatives containing plasma from that donor tested negative for SFV.

Original languageEnglish (US)
Pages (from-to)886-891
Number of pages6
JournalTransfusion
Volume42
Issue number7
StatePublished - Jul 2002
Externally publishedYes

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Simian foamy virus
Virus Diseases
Blood Donors
Primates
Blood Platelets
Infection
Tissue Donors
Viral RNA
Virulence
Albumins
Western Blotting

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Boneva, R. S., Grindon, A. J., Orton, S. L., Switzer, W. M., Shanmugam, V., Hussain, A. I., ... Chapman, L. E. (2002). Simian foamy virus infection in a blood donor. Transfusion, 42(7), 886-891.

Simian foamy virus infection in a blood donor. / Boneva, R. S.; Grindon, A. J.; Orton, S. L.; Switzer, W. M.; Shanmugam, Vedapuri; Hussain, A. I.; Bhullar, V. B.; Chamberland, M. E.; Heneine, Walid; Folks, T. M.; Chapman, L. E.

In: Transfusion, Vol. 42, No. 7, 07.2002, p. 886-891.

Research output: Contribution to journalArticle

Boneva, RS, Grindon, AJ, Orton, SL, Switzer, WM, Shanmugam, V, Hussain, AI, Bhullar, VB, Chamberland, ME, Heneine, W, Folks, TM & Chapman, LE 2002, 'Simian foamy virus infection in a blood donor.', Transfusion, vol. 42, no. 7, pp. 886-891.
Boneva RS, Grindon AJ, Orton SL, Switzer WM, Shanmugam V, Hussain AI et al. Simian foamy virus infection in a blood donor. Transfusion. 2002 Jul;42(7):886-891.
Boneva, R. S. ; Grindon, A. J. ; Orton, S. L. ; Switzer, W. M. ; Shanmugam, Vedapuri ; Hussain, A. I. ; Bhullar, V. B. ; Chamberland, M. E. ; Heneine, Walid ; Folks, T. M. ; Chapman, L. E. / Simian foamy virus infection in a blood donor. In: Transfusion. 2002 ; Vol. 42, No. 7. pp. 886-891.
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