Simian foamy virus infection in a blood donor

R. S. Boneva, A. J. Grindon, S. L. Orton, W. M. Switzer, Vedapuri Shanmugam, A. I. Hussain, V. B. Bhullar, M. E. Chamberland, Walid Heneine, T. M. Folks, L. E. Chapman

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations


    BACKGROUND: Infections with simian foamy virus (SFV) are widely prevalent in nonhuman primates. SFV infection was confirmed in a worker, occupationally exposed to nonhuman primates, who donated blood after the retrospectively documented date of infection. Human-to-human transmission of SFV through transfusion and its pathogenicity have not been studied. STUDY DESIGN AND METHODS: Recipients of blood from this donor were identified and blood samples from such recipients were tested for SFV infection by Western blot and PCR assay. RESULTS: One recipient of RBCs and another recipient of FFP had died; retroviral infections were not implicated. One platelet recipient could not be tested. Recipients of RBCs (two), a WBC-reduced RBC unit (one), and a platelet unit (one) tested SFV-negative 19 months to 7 years after transfusion. Tested recipients had transfusions 3 to 35 days after blood donation. Samples of one lot of albumin and three lots of plasma protein fraction (manufactured from recovered plasma from two donations) tested negative both for antibodies and for viral RNA. CONCLUSION: SFV transmission through transfusion was not identified among four recipients of cellular blood components from one SFV-infected donor. Derivatives containing plasma from that donor tested negative for SFV.

    Original languageEnglish (US)
    Pages (from-to)886-891
    Number of pages6
    Issue number7
    StatePublished - Jan 1 2002

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Hematology


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