Silent mutations make some noise

Siyuan Zheng; Hoon Kim; Roel G.W. Verhaak

doi:10.1016/j.cell.2014.02.037

Silent mutations make some noise

Siyuan Zheng
, Hoon Kim
, Roel G.W. Verhaak

Research output: Contribution to journal › Short survey › peer-review

44 Scopus citations

Abstract

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

Original language	English (US)
Pages (from-to)	1129-1131
Number of pages	3
Journal	Cell
Volume	156
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2014.02.037
State	Published - Mar 13 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2014.02.037

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@article{f55a5ebcfa0a4299bffbd15655e26a77,

title = "Silent mutations make some noise",

abstract = "Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.",

author = "Siyuan Zheng and Hoon Kim and Verhaak, \{Roel G.W.\}",

note = "Funding Information: We thank Lee Ann Chastain for assistance in manuscript editing. This work was supported by grant number U24 CA143883 from the United States National Institutes of Health/National Cancer Institute (MD Anderson TCGA Genome Data Analysis Center) and by generous funding from the H.A. and Mary K. Chapman Foundation and the Lorraine Dell Program in Bioinformatics for Personalization of Cancer Medicine. H.K. is supported, in part, by the Odyssey Program and the Theodore N. Law Endowment for Scientific Achievement at The University of Texas MD Anderson Cancer Center.",

year = "2014",

month = mar,

day = "13",

doi = "10.1016/j.cell.2014.02.037",

language = "English (US)",

volume = "156",

pages = "1129--1131",

journal = "Cell",

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TY - JOUR

T1 - Silent mutations make some noise

AU - Zheng, Siyuan

AU - Kim, Hoon

AU - Verhaak, Roel G.W.

N1 - Funding Information: We thank Lee Ann Chastain for assistance in manuscript editing. This work was supported by grant number U24 CA143883 from the United States National Institutes of Health/National Cancer Institute (MD Anderson TCGA Genome Data Analysis Center) and by generous funding from the H.A. and Mary K. Chapman Foundation and the Lorraine Dell Program in Bioinformatics for Personalization of Cancer Medicine. H.K. is supported, in part, by the Odyssey Program and the Theodore N. Law Endowment for Scientific Achievement at The University of Texas MD Anderson Cancer Center.

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

AB - Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

UR - https://www.scopus.com/pages/publications/84896360635

UR - https://www.scopus.com/pages/publications/84896360635#tab=citedBy

U2 - 10.1016/j.cell.2014.02.037

DO - 10.1016/j.cell.2014.02.037

M3 - Short survey

C2 - 24630716

AN - SCOPUS:84896360635

SN - 0092-8674

VL - 156

SP - 1129

EP - 1131

JO - Cell

JF - Cell

IS - 6

ER -

Silent mutations make some noise

Abstract

ASJC Scopus subject areas

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