Silent mutations make some noise

Siyuan Zheng, Hoon Kim, Roel G.W. Verhaak

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations

Abstract

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

Original languageEnglish (US)
Pages (from-to)1129-1131
Number of pages3
JournalCell
Volume156
Issue number6
DOIs
StatePublished - Mar 13 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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