Silent mutations make some noise

Siyuan Zheng, Hoon Kim, Roel G.W. Verhaak

Research output: Contribution to journalShort surveypeer-review

37 Scopus citations


Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

Original languageEnglish (US)
Pages (from-to)1129-1131
Number of pages3
Issue number6
StatePublished - Mar 13 2014

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Silent mutations make some noise'. Together they form a unique fingerprint.

Cite this