Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus)

Venkata S. Voruganti, Matthew J. Jorgensen, Jay R. Kaplan, Kylie Kavanagh, Larry L. Rudel, Ryan Temel, Lynn A. Fairbanks, Anthony G. Comuzzie

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys (Chlorocebus aethiops sabaeus; n = 309) from a multigenerational pedigreed colony initially fed with a plant-based diet, standard primate diet (18% calories from protein, 13% from fat, and 69% from carbohydrates), and subsequently challenged for 8 weeks with a diet modeled on the typical American diet (18% calories from protein, 35% from fat, and 47% from carbohydrates). Our results showed that although exposure to the challenge diet did not result in significant changes in weight, most lipid and glycemic biomarkers moved in an adverse direction (P < 0.01). Quantitative genetic analyses showed that cardiometabolic phenotypes were significantly heritable under both dietary conditions (P < 0.05), and there was significant evidence of G × D interaction for these phenotypes. We observed significant differences in the additive genetic variances for most lipid phenotypes (P < 10-4), indicating that the magnitude of genetic effects varies by diet. Furthermore, genetic correlations between diets differed significantly from 1 with respect to insulin, body weight, and some lipid phenotypes (P < 0.01). This implied that distinct genetic effects are involved in the regulation of these phenotypes under the two dietary conditions. These G × D effects confirm and extend previous observations in baboons (Papio sp.) and suggest that mimicking the typical human nutritional environment can reveal genetic influences that might not be observed in animals consuming standard, plant-based diets. Am. J. Primatol. 75:491-499, 2013.

Original languageEnglish (US)
Pages (from-to)491-499
Number of pages9
JournalAmerican Journal of Primatology
Volume75
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Cercopithecus aethiops
pedigree
genotype
diet
phenotype
lipids
plant-based diet
lipid
Papio
fat
effect
carbohydrate
carbohydrates
body weight
quantitative genetics
genetic variance
protein
genetic correlation
biomarkers
risk factor

Keywords

  • Genetic predisposition
  • Nutrient composition
  • Quantitative genetic analysis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). / Voruganti, Venkata S.; Jorgensen, Matthew J.; Kaplan, Jay R.; Kavanagh, Kylie; Rudel, Larry L.; Temel, Ryan; Fairbanks, Lynn A.; Comuzzie, Anthony G.

In: American Journal of Primatology, Vol. 75, No. 5, 05.2013, p. 491-499.

Research output: Contribution to journalArticle

Voruganti, Venkata S. ; Jorgensen, Matthew J. ; Kaplan, Jay R. ; Kavanagh, Kylie ; Rudel, Larry L. ; Temel, Ryan ; Fairbanks, Lynn A. ; Comuzzie, Anthony G. / Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). In: American Journal of Primatology. 2013 ; Vol. 75, No. 5. pp. 491-499.
@article{544009430c144c42ac512fe7c2fa6bd9,
title = "Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus)",
abstract = "Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys (Chlorocebus aethiops sabaeus; n = 309) from a multigenerational pedigreed colony initially fed with a plant-based diet, standard primate diet (18{\%} calories from protein, 13{\%} from fat, and 69{\%} from carbohydrates), and subsequently challenged for 8 weeks with a diet modeled on the typical American diet (18{\%} calories from protein, 35{\%} from fat, and 47{\%} from carbohydrates). Our results showed that although exposure to the challenge diet did not result in significant changes in weight, most lipid and glycemic biomarkers moved in an adverse direction (P < 0.01). Quantitative genetic analyses showed that cardiometabolic phenotypes were significantly heritable under both dietary conditions (P < 0.05), and there was significant evidence of G × D interaction for these phenotypes. We observed significant differences in the additive genetic variances for most lipid phenotypes (P < 10-4), indicating that the magnitude of genetic effects varies by diet. Furthermore, genetic correlations between diets differed significantly from 1 with respect to insulin, body weight, and some lipid phenotypes (P < 0.01). This implied that distinct genetic effects are involved in the regulation of these phenotypes under the two dietary conditions. These G × D effects confirm and extend previous observations in baboons (Papio sp.) and suggest that mimicking the typical human nutritional environment can reveal genetic influences that might not be observed in animals consuming standard, plant-based diets. Am. J. Primatol. 75:491-499, 2013.",
keywords = "Genetic predisposition, Nutrient composition, Quantitative genetic analysis",
author = "Voruganti, {Venkata S.} and Jorgensen, {Matthew J.} and Kaplan, {Jay R.} and Kylie Kavanagh and Rudel, {Larry L.} and Ryan Temel and Fairbanks, {Lynn A.} and Comuzzie, {Anthony G.}",
year = "2013",
month = "5",
doi = "10.1002/ajp.22125",
language = "English (US)",
volume = "75",
pages = "491--499",
journal = "American Journal of Primatology",
issn = "0275-2565",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus)

AU - Voruganti, Venkata S.

AU - Jorgensen, Matthew J.

AU - Kaplan, Jay R.

AU - Kavanagh, Kylie

AU - Rudel, Larry L.

AU - Temel, Ryan

AU - Fairbanks, Lynn A.

AU - Comuzzie, Anthony G.

PY - 2013/5

Y1 - 2013/5

N2 - Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys (Chlorocebus aethiops sabaeus; n = 309) from a multigenerational pedigreed colony initially fed with a plant-based diet, standard primate diet (18% calories from protein, 13% from fat, and 69% from carbohydrates), and subsequently challenged for 8 weeks with a diet modeled on the typical American diet (18% calories from protein, 35% from fat, and 47% from carbohydrates). Our results showed that although exposure to the challenge diet did not result in significant changes in weight, most lipid and glycemic biomarkers moved in an adverse direction (P < 0.01). Quantitative genetic analyses showed that cardiometabolic phenotypes were significantly heritable under both dietary conditions (P < 0.05), and there was significant evidence of G × D interaction for these phenotypes. We observed significant differences in the additive genetic variances for most lipid phenotypes (P < 10-4), indicating that the magnitude of genetic effects varies by diet. Furthermore, genetic correlations between diets differed significantly from 1 with respect to insulin, body weight, and some lipid phenotypes (P < 0.01). This implied that distinct genetic effects are involved in the regulation of these phenotypes under the two dietary conditions. These G × D effects confirm and extend previous observations in baboons (Papio sp.) and suggest that mimicking the typical human nutritional environment can reveal genetic influences that might not be observed in animals consuming standard, plant-based diets. Am. J. Primatol. 75:491-499, 2013.

AB - Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys (Chlorocebus aethiops sabaeus; n = 309) from a multigenerational pedigreed colony initially fed with a plant-based diet, standard primate diet (18% calories from protein, 13% from fat, and 69% from carbohydrates), and subsequently challenged for 8 weeks with a diet modeled on the typical American diet (18% calories from protein, 35% from fat, and 47% from carbohydrates). Our results showed that although exposure to the challenge diet did not result in significant changes in weight, most lipid and glycemic biomarkers moved in an adverse direction (P < 0.01). Quantitative genetic analyses showed that cardiometabolic phenotypes were significantly heritable under both dietary conditions (P < 0.05), and there was significant evidence of G × D interaction for these phenotypes. We observed significant differences in the additive genetic variances for most lipid phenotypes (P < 10-4), indicating that the magnitude of genetic effects varies by diet. Furthermore, genetic correlations between diets differed significantly from 1 with respect to insulin, body weight, and some lipid phenotypes (P < 0.01). This implied that distinct genetic effects are involved in the regulation of these phenotypes under the two dietary conditions. These G × D effects confirm and extend previous observations in baboons (Papio sp.) and suggest that mimicking the typical human nutritional environment can reveal genetic influences that might not be observed in animals consuming standard, plant-based diets. Am. J. Primatol. 75:491-499, 2013.

KW - Genetic predisposition

KW - Nutrient composition

KW - Quantitative genetic analysis

UR - http://www.scopus.com/inward/record.url?scp=84875670340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875670340&partnerID=8YFLogxK

U2 - 10.1002/ajp.22125

DO - 10.1002/ajp.22125

M3 - Article

C2 - 23315630

AN - SCOPUS:84875670340

VL - 75

SP - 491

EP - 499

JO - American Journal of Primatology

JF - American Journal of Primatology

SN - 0275-2565

IS - 5

ER -