SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis

Liza D. Morales, Karina Pena, Dae Joon Kim, Jonathan H. Lieman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Apoptosis is intimately connected to cell cycle regulation via the Retinoblastoma (Rb)-E2F pathway and thereby serves an essential role in tumor suppression by eliminating aberrant hyperproliferative cells. Upon loss of Rb activity, an apoptotic response can be elicited through both p53-dependent and p53-independent mechanisms. While much of this apoptotic response has been attributed to the p19ARF/p53 pathway, increasing evidence has supported the role of protein tyrosine phosphatases (PTPs) in contributing to the initiation of the Rb-E2F-associated apoptotic response. One protein tyrosine phosphatase, PTP-1B, which is induced by the Rb-E2F pathway, has been shown to contribute to a p53-independent apoptotic pathway by inactivating focal adhesion kinase. This report identifies two additional PTPs, SHP-2 and PTP-PEST, that are also directly activated by the Rb-E2F pathway and which can contribute to signal transduction during p53-independent apoptosis.

Original languageEnglish (US)
Pages (from-to)422-432
Number of pages11
JournalCellular and Molecular Biology Letters
Volume17
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • Apoptosis
  • E2F-1
  • Focal adhesion kinase
  • PTP-1B
  • PTP-PEST
  • PTPN1
  • PTPN11
  • PTPN12
  • Phosphatase
  • Rb
  • SHP-2
  • Tumor suppressor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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