TY - JOUR
T1 - Short-term oral ingestion of Ginkgo biloba extract (EGb 761) reduces malondialdehyde levels in washed platelets of type 2 diabetic subjects
AU - Kudolo, George B.
AU - Delaney, Diana
AU - Blodgett, Janet
N1 - Funding Information:
The nursing and dietetic care provided by the staff of the Frederic C. Bartter General Clinical Research Center at the South Texas Veterans Health Care Systems - Audie Murphy Division is appreciated. This study was supported by funds from the San Antonio Area Foundation and NIH grants M01-RR-01346 and R01-AT-00832 (National Center for Complementary and Alternative Medicine, NCCAM). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCCAM, or the National Institutes of Health.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/4
Y1 - 2005/4
N2 - We have recently reported that ingestion of Ginkgo biloba extract (EGb 761) (a) significantly reduced collagen-induced platelet aggregation and thromboxane B2 (TXB2) production in both non-diabetic individuals as well as those with type 2 diabetes mellitus (T2DM), (b) significantly reduced platelet malondialdehyde (MDA), an index of lipid peroxidation, in non-diabetic subjects. In the present study we report that ingestion of EGb 761 (120 mg daily for 3 months), significantly decreased platelet MDA-thiobarbituric acid reacting substances (TBARS) (41 ± 9 pmol/107 platelets versus 30 ± 11 pmol/107 platelets) (p < 0.005) in T2DM subjects with normal cholesterol levels (total cholesterol, 164 ± 22 mg/dl; age, 54 ± 9 years; BMI, 35.0 ± 8.8 kg/m2, n = 12). In T2DM subjects with high cholesterol (total cholesterol, 218 ± 15 mg/dl; age, 52 ± 5 years; BMI, 36.2 ± 6.6 kg/m2, n = 7), EGb 761 ingestion reduced the platelet TBARS from 29 ± 9 to 22 ± 9 pmol/107 platelets (p < 0.04). Because ingestion of EGb 761 did not alter platelet counts it is concluded that EGb 761, probably due to the flavonoid fraction, reduced the TBARS by inhibiting cyclooxygenase (COX)-1-mediated arachidonic acid oxygenation or by reducing the arachidonic acid pool. This is likely to lead to a reduction of platelet hyperactivity, a significant contributor to the development of cardiovascular disease in T2DM patients. Because of other reported beneficial properties of EGb 761, such as stimulation of pancreatic β-cell function in T2DM subjects with pancreatic exhaustion, it appears that T2DM subjects might benefit from ingesting EGb 761 as a dietary supplement.
AB - We have recently reported that ingestion of Ginkgo biloba extract (EGb 761) (a) significantly reduced collagen-induced platelet aggregation and thromboxane B2 (TXB2) production in both non-diabetic individuals as well as those with type 2 diabetes mellitus (T2DM), (b) significantly reduced platelet malondialdehyde (MDA), an index of lipid peroxidation, in non-diabetic subjects. In the present study we report that ingestion of EGb 761 (120 mg daily for 3 months), significantly decreased platelet MDA-thiobarbituric acid reacting substances (TBARS) (41 ± 9 pmol/107 platelets versus 30 ± 11 pmol/107 platelets) (p < 0.005) in T2DM subjects with normal cholesterol levels (total cholesterol, 164 ± 22 mg/dl; age, 54 ± 9 years; BMI, 35.0 ± 8.8 kg/m2, n = 12). In T2DM subjects with high cholesterol (total cholesterol, 218 ± 15 mg/dl; age, 52 ± 5 years; BMI, 36.2 ± 6.6 kg/m2, n = 7), EGb 761 ingestion reduced the platelet TBARS from 29 ± 9 to 22 ± 9 pmol/107 platelets (p < 0.04). Because ingestion of EGb 761 did not alter platelet counts it is concluded that EGb 761, probably due to the flavonoid fraction, reduced the TBARS by inhibiting cyclooxygenase (COX)-1-mediated arachidonic acid oxygenation or by reducing the arachidonic acid pool. This is likely to lead to a reduction of platelet hyperactivity, a significant contributor to the development of cardiovascular disease in T2DM patients. Because of other reported beneficial properties of EGb 761, such as stimulation of pancreatic β-cell function in T2DM subjects with pancreatic exhaustion, it appears that T2DM subjects might benefit from ingesting EGb 761 as a dietary supplement.
KW - EGb 761
KW - Ginkgo biloba
KW - Malondialdehyde
KW - Platelets
KW - Type 2 diabetes
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U2 - 10.1016/j.diabres.2004.08.007
DO - 10.1016/j.diabres.2004.08.007
M3 - Article
C2 - 15811563
AN - SCOPUS:16244375915
SN - 0168-8227
VL - 68
SP - 29
EP - 38
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -