Short report: Detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru

M. Saiz, A. Llanos-Cuentas, J. Echevarria, N. Roncal, M. Cruz, M. Tupayachi Muniz, C. Lucas, D. F. Wirth, S. Scheffter, A. J. Magill, J. L. Patterson

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    Leishmaniavirus is a double-stranded RNA virus that persistently infects some strains of the protozoan parasite Leishmania. There is considerable interest in the possibility that the presence of this virus alters parasite phenotype and may affect disease pathogenesis. If so, the virus marker could provide a valuable prognostic indicator for human leishmaniasis, particularly in those cases caused by New World parasite strains. The virus has been detected in cultured L. braziliensis, L. b. guyanensis, and L. major. To date there has been no information as to the extent of infection in samples prior to culturing in the laboratory. This study demonstrates, through the reverse transcription-polymerase chain reaction, that Leishmaniavirus exists in human biopsy samples of leishmaniasis prior to manipulation in culture.

    Original languageEnglish (US)
    Pages (from-to)192-194
    Number of pages3
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume58
    Issue number2
    DOIs
    StatePublished - Jan 1 1998

    ASJC Scopus subject areas

    • Parasitology
    • Virology
    • Infectious Diseases

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