Short-circuiting autoimmune disease by target-tissue-derived nitric oxide

Yvonne R. Garcia, Keith A. Krolick

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A previous report from this laboratory suggested that expression of skeletal-muscle-derived, inducible nitric oxide synthase (iNOS), is associated with resistance to the autoimmune model of myasthenia gravis (MG) demonstrated by Wistar Furth rats following the passive transfer of antibody reactive with the nicotinic acetylcholine receptor (AChR). The study reported below demonstrates an association between increased expression of iNOS/NO in Wistar Furth rats and the induction of programmed cell death (apoptosis) in both macrophages and CD4+ T cells that attempt to traffic through targeted muscles. It is concluded that production of muscle-derived NO is protective in experimental MG, and in part, dictates the severity of eventual immunopathology.

Original languageEnglish (US)
Pages (from-to)74-80
Number of pages7
JournalClinical Immunology
Volume113
Issue number1
DOIs
StatePublished - Oct 1 2004

Keywords

  • Autoimmune disease
  • Muscle disease
  • Myasthenia gravis
  • Nitric oxide
  • iNOS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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