Schichtarbeit und krebs hintergründe und herausforderungen

Translated title of the contribution: Shift work and cancer - The evidence and the challenge

Thomas C. Erren, Puran Falaturi, Peter Morfeld, Peter Knauth, Russel J. Reiter, Claus Piekarski

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Background: In 2007, the International Agency for Research on Cancer (IARC) classified shift work with circadian disruption or chronodisruption as a probable human carcinogen. Short-term disturbances of biological 24-hour-rhythms following exposures to light and darkness at unusual times are well-known as "jet-lag" and "shift-lag" symptoms. However, that chronic disturbances or disruptions of timely sequenced circadian rhythms (chronodisruption) should contribute to long-term developments of cancer is a relatively new concept. This review provides background and practical information with regard to the open question "does shift-work cause cancer?" Methods: Overview on the basis of a selective literature search via Medline and ISI Web of Knowledge until 2009 from the viewpoints of occupational medicine, epidemiology, chronobiology, and occupational science. Results: The postulated causal links between shift-work and cancer in humans are biologically plausible in the light of experimental findings, but to date we lack epidemiological studies which could describe or exonerate risks in humans. Monetary compensation has already been paid for such cases in at least one country (Denmark). In Germany, however, according to the applicable law, a new occupational disease can only be recognized when certain conditions for the recognition of "general scientific merit" have been met. We present the current state of knowledge regarding prevention. Conclusion: While causal links between shift-work and cancer developments are not established, future shift-work planning should pay more attention to insights from occupational medicine, chronobiology, and occupational science.

Translated title of the contributionShift work and cancer - The evidence and the challenge
Original languageGerman
Pages (from-to)657-662
Number of pages6
JournalDeutsches Arzteblatt
Issue number38
StatePublished - Sep 24 2010

ASJC Scopus subject areas

  • General Medicine


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