Shared Symptoms and Putative Biological Mechanisms in Chronic Liver Disease: Implications for Biobehavioral Research

Victoria Menzies, Nancy Jallo, Patricia Kinser, Jo Lynne W. Robins, Kyungeh An, Carolyn Driscoll, Angela Starkweather, Jasmohan S. Bajaj, Debra E. Lyon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Liver disease affects over 25 million people in the United States and, despite advances in medical management resulting in increased survival, a majority of these individuals report multiple co-occurring symptoms that severely impair functioning and quality of life. The purpose of this review is to (1) propose defining these co-occurring symptoms as a symptom cluster of chronic liver disease (CLD), (2) discuss putative underlying biological mechanisms related to CLD, including the liver–gut–brain axis and influence of the microbiome, and (3) discuss the implications for biobehavioral research in this patient population. Biobehavioral research focusing on the interrelated, and possibly synergistic, mechanisms of these symptoms may lead to the development and testing of targeted symptom management interventions for improving function and quality of life in this growing patient population.

Original languageEnglish (US)
Pages (from-to)222-229
Number of pages8
JournalBiological research for nursing
Volume17
Issue number2
DOIs
StatePublished - Mar 17 2015
Externally publishedYes

Keywords

  • biobehavioral
  • liver disease
  • mechanisms
  • symptoms

ASJC Scopus subject areas

  • Research and Theory

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