Shared genetic factors influence risk for bipolar disorder and alcohol use disorders

N. Carmiol, J. M. Peralta, L. Almasy, J. Contreras, A. Pacheco, M. A. Escamilla, E. E M Knowles, H. Raventós, D. C. Glahn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Bipolar disorder and alcohol use disorder (AUD) have a high rate of comorbidity, more than 50% of individuals with bipolar disorder also receive a diagnosis of AUD in their lifetimes. Although both disorders are heritable, it is unclear if the same genetic factors mediate risk for bipolar disorder and AUD. We examined 733 Costa Rican individuals from 61 bipolar pedigrees. Based on a best estimate process, 32% of the sample met criteria for bipolar disorder, 17% had a lifetime AUD diagnosis, 32% met criteria for lifetime nicotine dependence, and 21% had an anxiety disorder. AUD, nicotine dependence and anxiety disorders were relatively more common among individuals with bipolar disorder than in their non-bipolar relatives. All illnesses were shown to be heritable and bipolar disorder was genetically correlated with AUD, nicotine dependence and anxiety disorders. The genetic correlation between bipolar and AUD remained when controlling for anxiety, suggesting that unique genetic factors influence the risk for comorbid bipolar and AUD independent of anxiety. Our findings provide evidence for shared genetic effects on bipolar disorder and AUD risk. Demonstrating that common genetic factors influence these independent diagnostic constructs could help to refine our diagnostic nosology.

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalEuropean Psychiatry
Volume29
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

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Bipolar Disorder
Alcohols
Anxiety Disorders
Tobacco Use Disorder
Pedigree
Comorbidity
Anxiety

Keywords

  • Alcohol use disorder
  • Bipolar disorder
  • Central Valley of Costa Rica
  • Family studies
  • Genetic correlation
  • Heritability

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Carmiol, N., Peralta, J. M., Almasy, L., Contreras, J., Pacheco, A., Escamilla, M. A., ... Glahn, D. C. (2014). Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. European Psychiatry, 29(5), 282-287. https://doi.org/10.1016/j.eurpsy.2013.10.001

Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. / Carmiol, N.; Peralta, J. M.; Almasy, L.; Contreras, J.; Pacheco, A.; Escamilla, M. A.; Knowles, E. E M; Raventós, H.; Glahn, D. C.

In: European Psychiatry, Vol. 29, No. 5, 2014, p. 282-287.

Research output: Contribution to journalArticle

Carmiol, N, Peralta, JM, Almasy, L, Contreras, J, Pacheco, A, Escamilla, MA, Knowles, EEM, Raventós, H & Glahn, DC 2014, 'Shared genetic factors influence risk for bipolar disorder and alcohol use disorders', European Psychiatry, vol. 29, no. 5, pp. 282-287. https://doi.org/10.1016/j.eurpsy.2013.10.001
Carmiol N, Peralta JM, Almasy L, Contreras J, Pacheco A, Escamilla MA et al. Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. European Psychiatry. 2014;29(5):282-287. https://doi.org/10.1016/j.eurpsy.2013.10.001
Carmiol, N. ; Peralta, J. M. ; Almasy, L. ; Contreras, J. ; Pacheco, A. ; Escamilla, M. A. ; Knowles, E. E M ; Raventós, H. ; Glahn, D. C. / Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. In: European Psychiatry. 2014 ; Vol. 29, No. 5. pp. 282-287.
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