Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index

Karen Hodgson, Russell A. Poldrack, Joanne E. Curran, Emma E. Knowles, Samuel Mathias, Harald H.H. Göring, Nailin Yao, Rene L Olvera, Peter T Fox, Laura Almasy, Ravi Duggirala, Deanna M. Barch, John Blangero, David C. Glahn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Head movements are typically viewed as a nuisance to functional magnetic resonance imaging (fMRI) analysis, and are particularly problematic for resting state fMRI. However, there is growing evidence that head motion is a behavioral trait with neural and genetic underpinnings. Using data from a large randomly ascertained extended pedigree sample of Mexican Americans (n = 689), we modeled the genetic structure of head motion during resting state fMRI and its relation to 48 other demographic and behavioral phenotypes. A replication analysis was performed using data from the Human Connectome Project, which uses an extended twin design (n = 864). In both samples, head motion was significantly heritable (h2 = 0.313 and 0.427, respectively), and phenotypically correlated with numerous traits. The most strongly replicated relationship was between head motion and body mass index, which showed evidence of shared genetic influences in both data sets. These results highlight the need to view head motion in fMRI as a complex neurobehavioral trait correlated with a number of other demographic and behavioral phenotypes. Given this, when examining individual differences in functional connectivity, the confounding of head motion with other traits of interest needs to be taken into consideration alongside the critical important of addressing head motion artifacts.

Original languageEnglish (US)
Pages (from-to)5539-5546
Number of pages8
JournalCerebral cortex (New York, N.Y. : 1991)
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Body Mass Index
Head
Magnetic Resonance Imaging
Connectome
Demography
Phenotype
Head Movements
Genetic Structures
Pedigree
Individuality
Artifacts

Keywords

  • BMI
  • head motion
  • MRI

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Hodgson, K., Poldrack, R. A., Curran, J. E., Knowles, E. E., Mathias, S., Göring, H. H. H., ... Glahn, D. C. (2017). Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. Cerebral cortex (New York, N.Y. : 1991), 27(12), 5539-5546. https://doi.org/10.1093/cercor/bhw321

Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. / Hodgson, Karen; Poldrack, Russell A.; Curran, Joanne E.; Knowles, Emma E.; Mathias, Samuel; Göring, Harald H.H.; Yao, Nailin; Olvera, Rene L; Fox, Peter T; Almasy, Laura; Duggirala, Ravi; Barch, Deanna M.; Blangero, John; Glahn, David C.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 27, No. 12, 01.12.2017, p. 5539-5546.

Research output: Contribution to journalArticle

Hodgson, K, Poldrack, RA, Curran, JE, Knowles, EE, Mathias, S, Göring, HHH, Yao, N, Olvera, RL, Fox, PT, Almasy, L, Duggirala, R, Barch, DM, Blangero, J & Glahn, DC 2017, 'Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index', Cerebral cortex (New York, N.Y. : 1991), vol. 27, no. 12, pp. 5539-5546. https://doi.org/10.1093/cercor/bhw321
Hodgson K, Poldrack RA, Curran JE, Knowles EE, Mathias S, Göring HHH et al. Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. Cerebral cortex (New York, N.Y. : 1991). 2017 Dec 1;27(12):5539-5546. https://doi.org/10.1093/cercor/bhw321
Hodgson, Karen ; Poldrack, Russell A. ; Curran, Joanne E. ; Knowles, Emma E. ; Mathias, Samuel ; Göring, Harald H.H. ; Yao, Nailin ; Olvera, Rene L ; Fox, Peter T ; Almasy, Laura ; Duggirala, Ravi ; Barch, Deanna M. ; Blangero, John ; Glahn, David C. / Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. In: Cerebral cortex (New York, N.Y. : 1991). 2017 ; Vol. 27, No. 12. pp. 5539-5546.
@article{2fb2c76cd95d41e990841a9ff2a67d7d,
title = "Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index",
abstract = "Head movements are typically viewed as a nuisance to functional magnetic resonance imaging (fMRI) analysis, and are particularly problematic for resting state fMRI. However, there is growing evidence that head motion is a behavioral trait with neural and genetic underpinnings. Using data from a large randomly ascertained extended pedigree sample of Mexican Americans (n = 689), we modeled the genetic structure of head motion during resting state fMRI and its relation to 48 other demographic and behavioral phenotypes. A replication analysis was performed using data from the Human Connectome Project, which uses an extended twin design (n = 864). In both samples, head motion was significantly heritable (h2 = 0.313 and 0.427, respectively), and phenotypically correlated with numerous traits. The most strongly replicated relationship was between head motion and body mass index, which showed evidence of shared genetic influences in both data sets. These results highlight the need to view head motion in fMRI as a complex neurobehavioral trait correlated with a number of other demographic and behavioral phenotypes. Given this, when examining individual differences in functional connectivity, the confounding of head motion with other traits of interest needs to be taken into consideration alongside the critical important of addressing head motion artifacts.",
keywords = "BMI, head motion, MRI",
author = "Karen Hodgson and Poldrack, {Russell A.} and Curran, {Joanne E.} and Knowles, {Emma E.} and Samuel Mathias and G{\"o}ring, {Harald H.H.} and Nailin Yao and Olvera, {Rene L} and Fox, {Peter T} and Laura Almasy and Ravi Duggirala and Barch, {Deanna M.} and John Blangero and Glahn, {David C.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1093/cercor/bhw321",
language = "English (US)",
volume = "27",
pages = "5539--5546",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index

AU - Hodgson, Karen

AU - Poldrack, Russell A.

AU - Curran, Joanne E.

AU - Knowles, Emma E.

AU - Mathias, Samuel

AU - Göring, Harald H.H.

AU - Yao, Nailin

AU - Olvera, Rene L

AU - Fox, Peter T

AU - Almasy, Laura

AU - Duggirala, Ravi

AU - Barch, Deanna M.

AU - Blangero, John

AU - Glahn, David C.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Head movements are typically viewed as a nuisance to functional magnetic resonance imaging (fMRI) analysis, and are particularly problematic for resting state fMRI. However, there is growing evidence that head motion is a behavioral trait with neural and genetic underpinnings. Using data from a large randomly ascertained extended pedigree sample of Mexican Americans (n = 689), we modeled the genetic structure of head motion during resting state fMRI and its relation to 48 other demographic and behavioral phenotypes. A replication analysis was performed using data from the Human Connectome Project, which uses an extended twin design (n = 864). In both samples, head motion was significantly heritable (h2 = 0.313 and 0.427, respectively), and phenotypically correlated with numerous traits. The most strongly replicated relationship was between head motion and body mass index, which showed evidence of shared genetic influences in both data sets. These results highlight the need to view head motion in fMRI as a complex neurobehavioral trait correlated with a number of other demographic and behavioral phenotypes. Given this, when examining individual differences in functional connectivity, the confounding of head motion with other traits of interest needs to be taken into consideration alongside the critical important of addressing head motion artifacts.

AB - Head movements are typically viewed as a nuisance to functional magnetic resonance imaging (fMRI) analysis, and are particularly problematic for resting state fMRI. However, there is growing evidence that head motion is a behavioral trait with neural and genetic underpinnings. Using data from a large randomly ascertained extended pedigree sample of Mexican Americans (n = 689), we modeled the genetic structure of head motion during resting state fMRI and its relation to 48 other demographic and behavioral phenotypes. A replication analysis was performed using data from the Human Connectome Project, which uses an extended twin design (n = 864). In both samples, head motion was significantly heritable (h2 = 0.313 and 0.427, respectively), and phenotypically correlated with numerous traits. The most strongly replicated relationship was between head motion and body mass index, which showed evidence of shared genetic influences in both data sets. These results highlight the need to view head motion in fMRI as a complex neurobehavioral trait correlated with a number of other demographic and behavioral phenotypes. Given this, when examining individual differences in functional connectivity, the confounding of head motion with other traits of interest needs to be taken into consideration alongside the critical important of addressing head motion artifacts.

KW - BMI

KW - head motion

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=85049392574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049392574&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhw321

DO - 10.1093/cercor/bhw321

M3 - Article

VL - 27

SP - 5539

EP - 5546

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -