Shared and unique genetic effects among seven HDL phenotypes

Anthony G. Comuzzie, David L. Rainwater, John Blangero, Michael C. Mahaney, John L. Vandeberg, Jean W. MacCluer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The purpose of this study was to investigate the genetic control of various HDL measures and to determine the proportion of genetic variance explained by shared genes (ie, pleiotropy) and the proportion unique to each trait. The data used were drawn from large, randomly ascertained pedigrees of Mexican Americans participating in the San Antonio Family Heart Study. Data were available for 655 individuals (258 men and 397 women) in 26 families. We performed a multivariate quantitative genetic analysis to simultaneously estimate both the additive genetic and random environmental correlations among seven HDL phenotypes. These seven HDL phenotypes can be divided into two categories: measures of concentration and estimates of particle size. Concentration was measured for apo A-I, apo A-II, esterified cholesterol, and unesterified cholesterol, and particle size was estimated for apo A-I, apo A- II, and esterified cholesterol. The heritabilities (h2) for each of the seven traits were significantly greater than zero (P<.05) and ranged from 0.2 to 0.6. When considered in a pairwise fashion, all combinations of these traits showed marked genetic correlations (ρ(G)=0.33 to 0.87) and all were significantly greater than zero (P<.05), indicative of pleiotropic effects. However, we found substantial unique genetic variance for each of these traits even after accounting for the effects shared in common with all the remaining measures. We conclude that the genetic variation in these HDL phenotypes is a result of the action of common as well as unique genes.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume17
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Apolipoprotein A-II
Apolipoprotein A-I
Cholesterol
Phenotype
Particle Size
Pedigree
Genes

Keywords

  • apolipoproteins
  • HDL
  • multivariate
  • pleiotropy
  • quantitative genetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comuzzie, A. G., Rainwater, D. L., Blangero, J., Mahaney, M. C., Vandeberg, J. L., & MacCluer, J. W. (1997). Shared and unique genetic effects among seven HDL phenotypes. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(5), 859-864.

Shared and unique genetic effects among seven HDL phenotypes. / Comuzzie, Anthony G.; Rainwater, David L.; Blangero, John; Mahaney, Michael C.; Vandeberg, John L.; MacCluer, Jean W.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 17, No. 5, 1997, p. 859-864.

Research output: Contribution to journalArticle

Comuzzie, AG, Rainwater, DL, Blangero, J, Mahaney, MC, Vandeberg, JL & MacCluer, JW 1997, 'Shared and unique genetic effects among seven HDL phenotypes', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 5, pp. 859-864.
Comuzzie AG, Rainwater DL, Blangero J, Mahaney MC, Vandeberg JL, MacCluer JW. Shared and unique genetic effects among seven HDL phenotypes. Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17(5):859-864.
Comuzzie, Anthony G. ; Rainwater, David L. ; Blangero, John ; Mahaney, Michael C. ; Vandeberg, John L. ; MacCluer, Jean W. / Shared and unique genetic effects among seven HDL phenotypes. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1997 ; Vol. 17, No. 5. pp. 859-864.
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