Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. Objective The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Study Design A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. Results Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. Conclusion Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.

Original languageEnglish (US)
Pages (from-to)191.e1-191.e19
JournalAmerican Journal of Obstetrics and Gynecology
Volume217
Issue number2
DOIs
StatePublished - Aug 1 2017

Fingerprint

Polycystic Ovary Syndrome
Infertility
Androgens
Equipment and Supplies
Testosterone
National Institute of Child Health and Human Development (U.S.)
Sebum
Reproductive Medicine
Pregnancy
Hirsutism
Dehydroepiandrosterone
Ovulation Induction
Acne Vulgaris
Body Mass Index
Clinical Trials
Weights and Measures

Keywords

  • female sexual dysfunction
  • infertility
  • polycystic ovary syndrome
  • unexplained infertility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network (2017). Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. American Journal of Obstetrics and Gynecology, 217(2), 191.e1-191.e19. https://doi.org/10.1016/j.ajog.2017.04.034

Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network.

In: American Journal of Obstetrics and Gynecology, Vol. 217, No. 2, 01.08.2017, p. 191.e1-191.e19.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network 2017, 'Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility', American Journal of Obstetrics and Gynecology, vol. 217, no. 2, pp. 191.e1-191.e19. https://doi.org/10.1016/j.ajog.2017.04.034
Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. American Journal of Obstetrics and Gynecology. 2017 Aug 1;217(2):191.e1-191.e19. https://doi.org/10.1016/j.ajog.2017.04.034
Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. / Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. In: American Journal of Obstetrics and Gynecology. 2017 ; Vol. 217, No. 2. pp. 191.e1-191.e19.
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abstract = "Background While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. Objective The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Study Design A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. Results Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. Conclusion Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.",
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N2 - Background While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. Objective The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Study Design A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. Results Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. Conclusion Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.

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