Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Stephen B. Milam, Thomas B. Aufdemorte, Peter J. Sheridan, Robert G. Triplett, Joseph E. Van Sickels, G. Richard Holt

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume64
Issue number5
DOIs
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

Fingerprint Dive into the research topics of 'Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon'. Together they form a unique fingerprint.

  • Cite this