TY - JOUR
T1 - Sexual Dimorphism in N-Acetyltransferase Activity, Hydroxyindole-O-methyltransferase Activity, and Melatonin Content in the Harderian Gland of Syrian Hamsters
T2 - Changes following Gonadectomy
AU - Menendez-Pelaez, Armando
AU - Reiter, Russel J.
AU - Guerrero, Juan M.
AU - Puig-Domingo, Manuel
AU - Howes, Kimberly A.
N1 - Funding Information:
Supported by a FICYT Postdoctoral Fellowship from the Principado de Asturias Autonomous Government (Spain). 3
Funding Information:
Supported by a grant from the Fulbright Commission. 5
Funding Information:
Research supported by NSF Grant DCB 8410592. 2
PY - 1988/3
Y1 - 1988/3
N2 - The activities of N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) and the melatonin content of the Harderian glands of intact and gonadectomized male and female Syrian hamsters were studied. NAT activity in intact male Harderian glands was twice that of the female. Prepubertal or adult castrated males exhibited a decrease in NAT activity to a level comparable to that seen in the female. Testosterone implants in the castrated males led to a recovery of the original male NAT levels. Intact male hamsters had very low levels of Harderian HIOMT activity and melatonin content in comparison with the glands of the females. Prepubertal gonadectomy but not castration of adult males raised the levels of HIOMT activity and the melatonin content to those of the females. Bilateral ovariectomy had no effect on melatonin content, NAT activity, or HIOMT activity in the female hamster Harderian gland.
AB - The activities of N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) and the melatonin content of the Harderian glands of intact and gonadectomized male and female Syrian hamsters were studied. NAT activity in intact male Harderian glands was twice that of the female. Prepubertal or adult castrated males exhibited a decrease in NAT activity to a level comparable to that seen in the female. Testosterone implants in the castrated males led to a recovery of the original male NAT levels. Intact male hamsters had very low levels of Harderian HIOMT activity and melatonin content in comparison with the glands of the females. Prepubertal gonadectomy but not castration of adult males raised the levels of HIOMT activity and the melatonin content to those of the females. Bilateral ovariectomy had no effect on melatonin content, NAT activity, or HIOMT activity in the female hamster Harderian gland.
UR - http://www.scopus.com/inward/record.url?scp=0023976529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023976529&partnerID=8YFLogxK
U2 - 10.3181/00379727-187-42666
DO - 10.3181/00379727-187-42666
M3 - Article
C2 - 3347607
AN - SCOPUS:0023976529
SN - 0037-9727
VL - 187
SP - 287
EP - 291
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -