Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons

Anderson H. Kuo, Cun Li, Vicki Mattern, Hillary F. Huber, Anthony Comuzzie, Laura Cox, Matthias Schwab, Peter W. Nathanielsz, Geoffrey D Clarke

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5–6 years (human equivalent 20–24 years), skinfold thickness, and serum lipid profile at 8–9 years (human equivalent 32–36 years), comparing values with a normative life-course baboon cohort, 4–23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that reduced maternal diet accelerates offspring lipid changes in a sex-dimorphic manner. The interaction between programming and accelerated lipogenesis warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Jan 30 2018

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons'. Together they form a unique fingerprint.

  • Cite this