Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons

Anderson H. Kuo, Cun Li, Vicki Mattern, Hillary F. Huber, Anthony Comuzzie, Laura Cox, Matthias Schwab, Peter W. Nathanielsz, Geoffrey D Clarke

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5–6 years (human equivalent 20–24 years), skinfold thickness, and serum lipid profile at 8–9 years (human equivalent 32–36 years), comparing values with a normative life-course baboon cohort, 4–23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that reduced maternal diet accelerates offspring lipid changes in a sex-dimorphic manner. The interaction between programming and accelerated lipogenesis warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Jan 30 2018

Fingerprint

Papio
Lipids
Fats
Growth
Mothers
Diet
Skinfold Thickness
Lipogenesis
Subcutaneous Fat
LDL Lipoproteins
Lipid Metabolism
Lactation
LDL Cholesterol
Primates
Reference Values
Triglycerides
Magnetic Resonance Imaging
Phenotype
Pregnancy
Serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons. / Kuo, Anderson H.; Li, Cun; Mattern, Vicki; Huber, Hillary F.; Comuzzie, Anthony; Cox, Laura; Schwab, Matthias; Nathanielsz, Peter W.; Clarke, Geoffrey D.

In: International Journal of Obesity, 30.01.2018, p. 1-5.

Research output: Contribution to journalArticle

Kuo, Anderson H. ; Li, Cun ; Mattern, Vicki ; Huber, Hillary F. ; Comuzzie, Anthony ; Cox, Laura ; Schwab, Matthias ; Nathanielsz, Peter W. ; Clarke, Geoffrey D. / Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons. In: International Journal of Obesity. 2018 ; pp. 1-5.
@article{aacc0ce79af5477bb49fd6a5bdff01f8,
title = "Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons",
abstract = "Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70{\%} ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5–6 years (human equivalent 20–24 years), skinfold thickness, and serum lipid profile at 8–9 years (human equivalent 32–36 years), comparing values with a normative life-course baboon cohort, 4–23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that reduced maternal diet accelerates offspring lipid changes in a sex-dimorphic manner. The interaction between programming and accelerated lipogenesis warrants further investigation.",
author = "Kuo, {Anderson H.} and Cun Li and Vicki Mattern and Huber, {Hillary F.} and Anthony Comuzzie and Laura Cox and Matthias Schwab and Nathanielsz, {Peter W.} and Clarke, {Geoffrey D}",
year = "2018",
month = "1",
day = "30",
doi = "10.1038/s41366-018-0008-2",
language = "English (US)",
pages = "1--5",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons

AU - Kuo, Anderson H.

AU - Li, Cun

AU - Mattern, Vicki

AU - Huber, Hillary F.

AU - Comuzzie, Anthony

AU - Cox, Laura

AU - Schwab, Matthias

AU - Nathanielsz, Peter W.

AU - Clarke, Geoffrey D

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5–6 years (human equivalent 20–24 years), skinfold thickness, and serum lipid profile at 8–9 years (human equivalent 32–36 years), comparing values with a normative life-course baboon cohort, 4–23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that reduced maternal diet accelerates offspring lipid changes in a sex-dimorphic manner. The interaction between programming and accelerated lipogenesis warrants further investigation.

AB - Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5–6 years (human equivalent 20–24 years), skinfold thickness, and serum lipid profile at 8–9 years (human equivalent 32–36 years), comparing values with a normative life-course baboon cohort, 4–23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that reduced maternal diet accelerates offspring lipid changes in a sex-dimorphic manner. The interaction between programming and accelerated lipogenesis warrants further investigation.

UR - http://www.scopus.com/inward/record.url?scp=85042209036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042209036&partnerID=8YFLogxK

U2 - 10.1038/s41366-018-0008-2

DO - 10.1038/s41366-018-0008-2

M3 - Article

C2 - 29463919

AN - SCOPUS:85042209036

SP - 1

EP - 5

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -