Sex differences in brain structure in geriatric depression

Helen Lavretsky, Kristina Kurbanyan, Martina Ballmaier, Jim Mintz, Arthur Toga, Anand Kumar

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: In an exploratory study, authors compared patients with late-life major depression (MDD) and age-matched control subjects to examine sex differences in frontal and orbito-frontal (OFC) regional brain volumes. Methods: The study sample comprised 41 patients with MDD and 41 controls. Subjects underwent comprehensive neuropsychiatric examinations and magnetic resonance imaging (MRI) scans. Corrected frontal and OFC gray-matter volumes were compared among men and women in both groups. Results: The depression group had lower MMSE scores, greater severity of medical burden, apathy, psychomotor retardation, and poor health-related quality of life than the controls. Men in both groups had a greater severity of medical burden, apathy, and psychomotor retardation than women. The depression group had smaller OFC total and gray-matter volumes than the controls after matching for age. Men had smaller frontal-matter volumes than women in both groups. The diagnosis × sex interaction in brain regional volumes was observed only after controlling for medical burden. Conclusions: Sex differences in brain neuroanatomy may be important in the pathophysiology of geriatric depression. Men may be susceptible to atrophy in frontal subregions. Medical burden may contribute to the diagnosis X sex interaction in brain regional volumes.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume12
Issue number6
StatePublished - 2004
Externally publishedYes

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Sex Characteristics
Geriatrics
Depression
Apathy
Brain
Neuroanatomy
Quality Control
Atrophy
Quality of Life
Magnetic Resonance Imaging
Gray Matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Lavretsky, H., Kurbanyan, K., Ballmaier, M., Mintz, J., Toga, A., & Kumar, A. (2004). Sex differences in brain structure in geriatric depression. American Journal of Geriatric Psychiatry, 12(6), 653-657.

Sex differences in brain structure in geriatric depression. / Lavretsky, Helen; Kurbanyan, Kristina; Ballmaier, Martina; Mintz, Jim; Toga, Arthur; Kumar, Anand.

In: American Journal of Geriatric Psychiatry, Vol. 12, No. 6, 2004, p. 653-657.

Research output: Contribution to journalArticle

Lavretsky, H, Kurbanyan, K, Ballmaier, M, Mintz, J, Toga, A & Kumar, A 2004, 'Sex differences in brain structure in geriatric depression', American Journal of Geriatric Psychiatry, vol. 12, no. 6, pp. 653-657.
Lavretsky H, Kurbanyan K, Ballmaier M, Mintz J, Toga A, Kumar A. Sex differences in brain structure in geriatric depression. American Journal of Geriatric Psychiatry. 2004;12(6):653-657.
Lavretsky, Helen ; Kurbanyan, Kristina ; Ballmaier, Martina ; Mintz, Jim ; Toga, Arthur ; Kumar, Anand. / Sex differences in brain structure in geriatric depression. In: American Journal of Geriatric Psychiatry. 2004 ; Vol. 12, No. 6. pp. 653-657.
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