TY - JOUR
T1 - Sex-dependent cognitive performance in baboon offspring following maternal caloric restriction in pregnancy and lactation
AU - Rodriguez, Jesse S.
AU - Bartlett, Thad Q.
AU - Keenan, Kathryn E.
AU - Nathanielsz, Peter W.
AU - Nijland, Mark J.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: supported by NICHD 21350 (PWN, MJN), NICHD 57480 (TQB, KEK, MJN) and a NIH Postdoctoral supplement (NICHD 21350) to JSR. Funding source had no involvement in study design, data collection, analysis or interpretation.
PY - 2012/5
Y1 - 2012/5
N2 - In humans a suboptimal diet during development has negative outcomes in offspring. We investigated the behavioral outcomes in baboons born to mothers undergoing moderate maternal nutrient restriction (MNR). Maternal nutrient restriction mothers (n = 7) were fed 70% of food eaten by controls (CTR, n = 12) fed ad libitum throughout gestation and lactation. At 3.3 ± 0.2 (mean ± standard error of the mean [SEM]) years of age offspring (controls: female [FC, n = 8], male [MC, n = 4]; nutrient restricted: female [FR, n = 3] and male [MR, n = 4]) were administered progressive ratio, simple discrimination, intra-/extra-dimension set shift and delayed matching to sample tasks to assess motivation, learning, attention, and working memory, respectively. A treatment effect was observed in MNR offspring who demonstrated less motivation and impaired working memory. Nutrient-restricted female offspring showed improved learning, while MR offspring showed impaired learning and attentional set shifting and increased impulsivity. In summary, 30% restriction in maternal caloric intake has long lasting neurobehavioral outcomes in adolescent male baboon offspring.
AB - In humans a suboptimal diet during development has negative outcomes in offspring. We investigated the behavioral outcomes in baboons born to mothers undergoing moderate maternal nutrient restriction (MNR). Maternal nutrient restriction mothers (n = 7) were fed 70% of food eaten by controls (CTR, n = 12) fed ad libitum throughout gestation and lactation. At 3.3 ± 0.2 (mean ± standard error of the mean [SEM]) years of age offspring (controls: female [FC, n = 8], male [MC, n = 4]; nutrient restricted: female [FR, n = 3] and male [MR, n = 4]) were administered progressive ratio, simple discrimination, intra-/extra-dimension set shift and delayed matching to sample tasks to assess motivation, learning, attention, and working memory, respectively. A treatment effect was observed in MNR offspring who demonstrated less motivation and impaired working memory. Nutrient-restricted female offspring showed improved learning, while MR offspring showed impaired learning and attentional set shifting and increased impulsivity. In summary, 30% restriction in maternal caloric intake has long lasting neurobehavioral outcomes in adolescent male baboon offspring.
KW - attention
KW - developmental programming
KW - learning
KW - memory
KW - motivation
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U2 - 10.1177/1933719111424439
DO - 10.1177/1933719111424439
M3 - Article
C2 - 22344725
AN - SCOPUS:84860446772
VL - 19
SP - 493
EP - 504
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 5
ER -