Severity of hematuria effects resolution in patients treated with hyperbaric oxygen therapy for radiation-induced hematuria

Michael A. Liss, Kathryn Osann, Jane Cho, Walter C. Chua, Atreya Dash

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Introduction: We investigated the differences between prostate cancer patients with radiation-induced hematuria treated with hyperbaric oxygen (HBO) therapy that did or did not have a resolution of hematuria. Materials and Methods: We performed a retrospective review of prostate cancer patients with radiation-induced hematuria who underwent HBO from April 2000 to March 2010. We performed an analysis of demographic data and severity of hematuria in those who had resolution of or persistent hematuria. Additionally, prostate-specific antigen (PSA) data were also obtained during the study period. Results: Overall, 11/22 men had resolution of hematuria after HBO therapy with a median follow-up of 2.2 (0.35-13.6) years. The Radiation Therapy Oncology Group (RTOG) grade of hematuria is predictive of final hematuria outcome (resolution vs. persistent) after HBO (p = 0.026). No significant PSA changes were noted before and after HBO therapy. Conclusions: The RTOG hematuria grade is associated with the resolution of hematuria after HBO therapy for radiation-induced hematuria in men treated for prostate cancer. This information may be helpful during shared medical decision-making regarding utility of HBO therapy in the context of severity of hematuria.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalUrologia Internationalis
Volume91
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Hematuria
  • Hyperbaric oxygen
  • Prostate-specific antigen
  • Radiation cystitis

ASJC Scopus subject areas

  • Urology

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