Abstract
A patient with rheumatoid arthritis developed life-threatening pancytopenia resulting from low dose oral methotrexate (MTX) toxicity potentiated by probenecid. Clinically significant drug interactions are not frequently cited as risk factors for MTX hematologic toxicity. As low dose MTX is gaining increasing popularity in the rheumatologic practice, these potentially serious interactions should be considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 609-610 |
| Number of pages | 2 |
| Journal | Journal of Rheumatology |
| Volume | 18 |
| Issue number | 4 |
| State | Published - 1991 |
| Externally published | Yes |
Keywords
- Drug interactions
- Drug toxicity
- Methotrexate
- Pancytopenia
- Probenecid
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology