Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury

Lauren Destino, Deanna A. Sutton, Anna L. Helon, Peter L. Havens, John G. Thometz, Rodney E. Willoughby, Michael J. Chusid

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21 Scopus citations

Abstract

Background: Traumatic injuries occurring in agricultural settings are often associated with infections caused by unusual organisms. Such agents may be difficult to isolate, identify, and treat effectively. Case report: A 4-year-old boy developed an extensive infection of his knee and distal femur following a barnyard pitchfork injury. Ultimately the primary infecting agent was determined to be Myceliophthora thermophila a thermophilic melanized hyphomycete, rarely associated with human infection, found in animal excreta. Because of resistance to standard antifungal agents including amphotericin B and caspofungin, therapy was instituted with a prolonged course of terbinafine and voriconazole. Voriconazole blood levels demonstrated that the patient required a drug dosage (13.4 mg/kg) several fold greater than that recommended for adults in order to attain therapeutic blood levels. Conclusion: Unusual pathogens should be sought following traumatic farm injuries. Pharmacokinetic studies may be of critical importance when utilizing antifungal therapy with agents for which little information exists regarding drug metabolism in children.

Original languageEnglish (US)
Article number21
JournalAnnals of Clinical Microbiology and Antimicrobials
Volume5
DOIs
Publication statusPublished - Sep 8 2006

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Destino, L., Sutton, D. A., Helon, A. L., Havens, P. L., Thometz, J. G., Willoughby, R. E., & Chusid, M. J. (2006). Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury. Annals of Clinical Microbiology and Antimicrobials, 5, [21]. https://doi.org/10.1186/1476-0711-5-21