Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity

Natalia E. Schlabritz-Loutsevitch, Anthony G. Comuzzie, Michael M. Mahaney, Gene B. Hubbard, Edward J. Dick, Mehmet Kocak, Sonali Gupta, Maira Carrillo, Mauro Schenone, Arnold Postlethwaite, Andrzej Slominski

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalComparative Medicine
Volume66
Issue number2
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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    Schlabritz-Loutsevitch, N. E., Comuzzie, A. G., Mahaney, M. M., Hubbard, G. B., Dick, E. J., Kocak, M., Gupta, S., Carrillo, M., Schenone, M., Postlethwaite, A., & Slominski, A. (2016). Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity. Comparative Medicine, 66(2), 137-142.